In Vivo Structure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors J Hao, JN Ho, JA Lewis, KA Karim, RN Daniels, PR Gentry, CR Hopkins, ... ACS chemical biology 5 (2), 245-253, 2010 | 437 | 2010 |
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery BJ Melancon, CR Hopkins, MR Wood, KA Emmitte, CM Niswender, ... Journal of medicinal chemistry 55 (4), 1445-1464, 2012 | 254 | 2012 |
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels M Miller, J Shi, Y Zhu, M Kustov, J Tian, A Stevens, M Wu, J Xu, S Long, ... Journal of Biological Chemistry 286 (38), 33436-33446, 2011 | 215 | 2011 |
“Molecular switches” on mGluR allosteric ligands that modulate modes of pharmacology MR Wood, CR Hopkins, JT Brogan, PJ Conn, CW Lindsley Biochemistry 50 (13), 2403-2410, 2011 | 182 | 2011 |
Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors CW Lindsley, KA Emmitte, CR Hopkins, TM Bridges, KJ Gregory, ... Chemical reviews 116 (11), 6707-6741, 2016 | 176 | 2016 |
Inhibition of the TRPC5 ion channel protects the kidney filter T Schaldecker, S Kim, C Tarabanis, D Tian, S Hakroush, P Castonguay, ... The Journal of clinical investigation 123 (12), 5298-5309, 2013 | 176 | 2013 |
Advancing biological understanding and therapeutics discovery with small-molecule probes SL Schreiber, JD Kotz, M Li, J Aubé, CP Austin, JC Reed, H Rosen, ... Cell 161 (6), 1252-1265, 2015 | 164 | 2015 |
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models Y Zhou, P Castonguay, EH Sidhom, AR Clark, M Dvela-Levitt, S Kim, ... Science 358 (6368), 1332-1336, 2017 | 148 | 2017 |
DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction MD Neely, MJ Litt, AM Tidball, GG Li, AA Aboud, CR Hopkins, ... ACS chemical neuroscience 3 (6), 482-491, 2012 | 130 | 2012 |
The discovery and characterization of ML218: a novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson’s … Z Xiang, AD Thompson, JT Brogan, ML Schulte, BJ Melancon, D Mi, ... ACS chemical neuroscience 2 (12), 730-742, 2011 | 118 | 2011 |
Inhibition of BMP signaling suppresses metastasis in mammary cancer P Owens, MW Pickup, SV Novitskiy, JM Giltnane, AE Gorska, CR Hopkins, ... Oncogene 34 (19), 2437-2449, 2015 | 115 | 2015 |
Selective Inhibition of the Kir2 Family of Inward Rectifier Potassium Channels by a Small Molecule Probe: The Discovery, SAR, and Pharmacological … HR Wang, M Wu, H Yu, S Long, A Stevens, DW Engers, H Sackin, ... ACS chemical biology 6 (8), 845-856, 2011 | 103 | 2011 |
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in … CK Jones, M Bubser, AD Thompson, JW Dickerson, N Turle-Lorenzo, ... Journal of Pharmacology and Experimental Therapeutics 340 (2), 404-421, 2012 | 98 | 2012 |
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs) DW Engers, CM Niswender, CD Weaver, S Jadhav, UN Menon, ... Journal of medicinal chemistry 52 (14), 4115-4118, 2009 | 91 | 2009 |
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels H Yu, Z Lin, ME Mattmann, B Zou, C Terrenoire, H Zhang, M Wu, ... Proceedings of the National Academy of Sciences 110 (21), 8732-8737, 2013 | 86 | 2013 |
Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo [1.5-a] pyrimidine … DW Engers, AY Frist, CW Lindsley, CC Hong, CR Hopkins Bioorganic & medicinal chemistry letters 23 (11), 3248-3252, 2013 | 85 | 2013 |
mGluR4-positive allosteric modulation as potential treatment for Parkinson’s disease CR Hopkins, CW Lindsley, CM Niswender Future medicinal chemistry 1 (3), 501-513, 2009 | 81 | 2009 |
Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels R Raphemot, MF Rouhier, CR Hopkins, RD Gogliotti, KM Lovell, RM Hine, ... PloS one 8 (5), e64905, 2013 | 77 | 2013 |
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis CR Hopkins, SV O’Neil, MC Laufersweiler, Y Wang, M Pokross, M Mekel, ... Bioorganic & Medicinal Chemistry Letters 16 (21), 5659-5663, 2006 | 76 | 2006 |
An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria DR Swale, DW Engers, SR Bollinger, A Gross, EA Inocente, E Days, ... Scientific reports 6 (1), 36954, 2016 | 73 | 2016 |