MeCP2 binding to DNA depends upon hydration at methyl-CpG KL Ho, IW McNae, L Schmiedeberg, RJ Klose, AP Bird, MD Walkinshaw Molecular cell 29 (4), 525-531, 2008 | 302 | 2008 |
Gene encoding a deubiquitinating enzyme is mutated in artesunate‐ and chloroquine‐resistant rodent malaria parasites§ P Hunt, A Afonso, A Creasey, R Culleton, ABS Sidhu, J Logan, ... Molecular microbiology 65 (1), 27-40, 2007 | 203 | 2007 |
2-Anilino-4-(thiazol-5-yl) pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity S Wang, C Meades, G Wood, A Osnowski, S Anderson, R Yuill, M Thomas, ... Journal of medicinal chemistry 47 (7), 1662-1675, 2004 | 197 | 2004 |
Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop SY Wu, I McNae, G Kontopidis, SJ McClue, C McInnes, KJ Stewart, ... Structure 11 (4), 399-410, 2003 | 159 | 2003 |
Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity R Jorda, L Havlicek, IW McNae, MD Walkinshaw, J Voller, A Sturc, ... Journal of medicinal chemistry 54 (8), 2980-2993, 2011 | 101 | 2011 |
Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme TM Hunter, IW McNae, X Liang, J Bella, S Parsons, MD Walkinshaw, ... Proceedings of the National Academy of Sciences 102 (7), 2288-2292, 2005 | 91 | 2005 |
Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model HP Morgan, IW McNae, MW Nowicki, V Hannaert, PAM Michels, ... Journal of biological chemistry 285 (17), 12892-12898, 2010 | 90 | 2010 |
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site HP Morgan, IW McNae, MW Nowicki, W Zhong, PAM Michels, DS Auld, ... Journal of Biological Chemistry 286 (36), 31232-31240, 2011 | 86 | 2011 |
Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives CJ Brown, I McNae, PM Fischer, MD Walkinshaw Journal of molecular biology 372 (1), 7-15, 2007 | 85 | 2007 |
Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis MW Nowicki, LB Tulloch, L Worralll, IW McNae, V Hannaert, PAM Michels, ... Bioorganic & medicinal chemistry 16 (9), 5050-5061, 2008 | 84 | 2008 |
Antiproliferative activity of olomoucine II, a novel 2, 6, 9-trisubstituted purine cyclin-dependent kinase inhibitor V Kryštof, IW McNae, MD Walkinshaw, PM Fischer, P Müller, B Vojtěšek, ... Cellular and Molecular Life Sciences CMLS 62, 1763-1771, 2005 | 84 | 2005 |
Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design G Kontopidis, C McInnes, SR Pandalaneni, I McNae, D Gibson, M Mezna, ... Chemistry & biology 13 (2), 201-211, 2006 | 74 | 2006 |
Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors S Wang, G Wood, C Meades, G Griffiths, C Midgley, I McNae, C McInnes, ... Bioorganic & medicinal chemistry letters 14 (16), 4237-4240, 2004 | 71 | 2004 |
Configurations of Nickel–cyclam antiviral complexes and protein recognition TM Hunter, IW McNae, DP Simpson, AM Smith, S Moggach, F White, ... Chemistry–A European Journal 13 (1), 40-50, 2007 | 70 | 2007 |
A recombinant C121S mutant of bovine β-lactoglobulin is more susceptible to peptic digestion and to denaturation by reducing agents and heating D Jayat, JC Gaudin, JM Chobert, TV Burova, C Holt, I McNae, L Sawyer, ... Biochemistry 43 (20), 6312-6321, 2004 | 68 | 2004 |
Apparent chemical composition of nine commercial or semi‐commercial whey protein concentrates, isolates and fractions C Holt, D McPhail, I Nevison, T Nylander, J Otte, RH Ipsen, R Bauer, ... International journal of food science & technology 34 (5‐6), 543-556, 1999 | 67 | 1999 |
Half-sandwich arene ruthenium (II)–enzyme complex IW McNae, K Fishburne, A Habtemariam, TM Hunter, M Melchart, F Wang, ... Chemical communications, 1786-1787, 2004 | 64 | 2004 |
Bivalent enzyme inhibitors discovered using dynamic covalent chemistry AJ Clipson, VT Bhat, I McNae, AM Caniard, DJ Campopiano, MF Greaney Chemistry–A European Journal 18 (34), 10562-10570, 2012 | 59 | 2012 |
An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor M Yuan, IW McNae, Y Chen, EA Blackburn, MA Wear, PAM Michels, ... Biochemical Journal 475 (10), 1821-1837, 2018 | 56 | 2018 |
Some physico‐chemical properties of nine commercial or semi‐commercial whey protein concentrates, isolates and fractions C Holt, D McPhail, T Nylander, J Otte, RH Ipsen, R Bauer, L Øgendal, ... International journal of food science & technology 34 (5‐6), 587-601, 1999 | 56 | 1999 |