Marius C. Hoener
Marius C. Hoener
Ph.D., Distinguished Scientist, Head of Exploratory Biology, Drug Discovery Project Team Leader
Email confirmado em roche.com
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Pharmacological characterization of designer cathinones in vitro
LD Simmler, TA Buser, M Donzelli, Y Schramm, LH Dieu, J Huwyler, ...
British journal of pharmacology 168 (2), 458-470, 2013
5932013
A renaissance in trace amines inspired by a novel GPCR family
L Lindemann, MC Hoener
Trends in pharmacological sciences 26 (5), 274-281, 2005
2782005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of α-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
R Ved, S Saha, B Westlund, C Perier, L Burnam, A Sluder, M Hoener, ...
Journal of Biological Chemistry 280 (52), 42655-42668, 2005
2722005
Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors
L Lindemann, M Ebeling, NA Kratochwil, JR Bunzow, DK Grandy, ...
Genomics 85 (3), 372-385, 2005
2622005
Trace amine-associated receptor 1 modulates dopaminergic activity
L Lindemann, CA Meyer, K Jeanneau, A Bradaia, L Ozmen, ...
Journal of Pharmacology and Experimental Therapeutics 324 (3), 948-956, 2008
2532008
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity
FG Revel, JL Moreau, RR Gainetdinov, A Bradaia, TD Sotnikova, R Mory, ...
Proceedings of the national academy of sciences 108 (20), 8485-8490, 2011
2332011
Caenorhabditis elegans MPP+ model of Parkinson’s disease for high-throughput drug screenings
E Braungart, M Gerlach, P Riederer, R Baumeister, MC Hoener
Neurodegenerative diseases 1 (4-5), 175-183, 2004
1892004
Monoamine transporter and receptor interaction profiles of a new series of designer cathinones
LD Simmler, A Rickli, MC Hoener, ME Liechti
Neuropharmacology 79, 152-160, 2014
1842014
A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic-and antidepressant-like activity, improve cognition and control body weight
FG Revel, JL Moreau, B Pouzet, R Mory, A Bradaia, D Buchy, V Metzler, ...
Molecular psychiatry 18 (5), 543-556, 2013
1692013
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system
A Bradaia, G Trube, H Stalder, RD Norcross, L Ozmen, JG Wettstein, ...
Proceedings of the National Academy of Sciences 106 (47), 20081-20086, 2009
1672009
Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones
A Rickli, MC Hoener, ME Liechti
European Neuropsychopharmacology 25 (3), 365-376, 2015
1582015
The norepinephrine transporter inhibitor reboxetine reduces stimulant effects of MDMA (“ecstasy”) in humans
CM Hysek, LD Simmler, M Ineichen, E Grouzmann, MC Hoener, ...
Clinical pharmacology & therapeutics 90 (2), 246-255, 2011
1432011
Duloxetine Inhibits Effects of MDMA (“Ecstasy") In Vitro and in Humans in a Randomized Placebo-Controlled Laboratory Study
CM Hysek, LD Simmler, VG Nicola, N Vischer, M Donzelli, S Krähenbühl, ...
PloS one 7 (5), e36476, 2012
1392012
Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity‐dependent neuronal plasticity
O Griesbeck, M Canossa, G Campana, A Gärtner, MC Hoener, H Nawa, ...
Microscopy research and technique 45 (4‐5), 262-275, 1999
1391999
Trace amines and their receptors
RR Gainetdinov, MC Hoener, MD Berry
Pharmacological reviews 70 (3), 549-620, 2018
1302018
Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens
A Rickli, OD Moning, MC Hoener, ME Liechti
European Neuropsychopharmacology 26 (8), 1327-1337, 2016
1232016
Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2, 5-dimethoxy-substituted phenethylamines (2C drugs)
A Rickli, D Luethi, J Reinisch, D Buchy, MC Hoener, ME Liechti
Neuropharmacology 99, 546-553, 2015
1222015
Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics
FG Revel, JL Moreau, RR Gainetdinov, A Ferragud, ...
Biological psychiatry 72 (11), 934-942, 2012
1132012
Pharmacology of human trace amine-associated receptors: therapeutic opportunities and challenges
MD Berry, RR Gainetdinov, MC Hoener, M Shahid
Pharmacology & therapeutics 180, 161-180, 2017
1042017
The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf+/− heterozygous null mice
JSO Lindholm, H Autio, L Vesa, H Antila, L Lindemann, MC Hoener, ...
Neuropharmacology 62 (1), 391-397, 2012
972012
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