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Alison Mbekeani
Alison Mbekeani
Researcher
Email confirmado em durham.ac.uk
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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
GA Biagini, N Fisher, AE Shone, MA Mubaraki, A Srivastava, A Hill, ...
Proceedings of the National Academy of Sciences 109 (21), 8298-8303, 2012
1932012
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum Type II NADH: quinone oxidoreductase (PfNDH2)
C Pidathala, R Amewu, B Pacorel, GL Nixon, P Gibbons, WD Hong, ...
Journal of Medicinal Chemistry, 2012
1292012
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH: Quinone Oxidoreductase (PfNDH2)
SC Leung, P Gibbons, R Amewu, GL Nixon, C Pidathala, WD Hong, ...
Journal of Medicinal Chemistry, 2012
692012
Cryopreservation-related loss of antigen-specific IFNγ producing CD4+ T-cells can skew immunogenicity data in vaccine trials: Lessons from a malaria vaccine trial substudy
T Ford, C Wenden, A Mbekeani, L Dally, JH Cox, M Morin, N Winstone, ...
Vaccine 35 (15), 1898-1906, 2017
432017
Complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the leishmania metabolome caused by miltefosine
EG Armitage, AQI Alqaisi, J Godzien, I Peña, AJ Mbekeani, ...
Antimicrobial Agents and Chemotherapy 62 (5), 10.1128/aac. 02095-17, 2018
382018
Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High Throughput Screening Program against the Novel Malarial Target, PfNDH2 …
R Sharma, AS Lawrenson, N Fisher, A Warman, AE Shone, A Hill, ...
Journal of Medicinal Chemistry, 2012
322012
The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis
AQI Alqaisi, AJ Mbekeani, MB Llorens, AP Elhammer, PW Denny
Parasitology 145 (2), 148-155, 2018
212018
Mining for natural product antileishmanials in a fungal extract library
AJ Mbekeani, RS Jones, MB Llorens, J Elliot, C Regnault, MP Barrett, ...
International Journal for Parasitology: Drugs and Drug Resistance 11, 118-128, 2019
112019
Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii
AJ Mbekeani, WA Stanley, VC Kalel, N Dahan, E Zalckvar, L Sheiner, ...
Genes 9 (9), 434, 2018
22018
A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH: ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum
H Alasdair, M Alison, S Alison, N Gemma, S Paul, G Peter, A Richard, ...
Malaria Journal 9, 2010
22010
Investigating Toxoplasma gondii peroxisome and the discovery of two Bisabolane Sesquiterpenes as anti-leshmanials.
A MBEKEANI
Durham University, 2020
2020
IJP: Drugs and Drug Resistance
AJ Mbekeani, RS Jones, MB Llorens, J Elliot, C Regnault, MP Barrett, ...
2019
CRYOPRESERVATION RELATED LOSS OF ANTIGEN SPECIFIC IFN gamma PRODUCING CD4+ T-CELLS: LESSONS FROM A MALARIA VACCINE TRIAL SUBSTUDY
TP Ford, C Wenden, A Mbekeani, L Dally, JH Cox, N Winstone, ...
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 95 (5), 314-314, 2017
2017
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH: quinone oxidoreductase (PfNDH2).
CP Chandrakala Pidathala, R Amewu, B Pacorel, GL Nixon, P Gibbons, ...
2012
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH: quinone oxidoreductase
GA Biagini, A Hill, A Mbekeani, A Shone, G Nixon, P Stocks, P Gibbons, ...
Malaria Journal 9, 1-1, 2010
2010
View metadata, citation and similar papers at core. ac. uk
N Messadeq, J Milne, P Lambert, P Elliott, B Geny, M Laakso, N Fisher, ...
9P. 3 A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH: ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum
N Fisher, A Hill, A Mbekeani, A Shone, G Nixon, P Stocks, P Gibbons, ...
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH: quinone oxidoreductase
B Giancarlo, H Alasdair, M Alison, S Alison, N Gemma, S Paul, G Peter, ...
Malaria Journal 9, 0
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Artigos 1–18