Michael Wolfe
Michael Wolfe
Professor of Medicinal Chemistry, University of Kansas
Email confirmado em ku.edu - Página inicial
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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
DM Walsh, I Klyubin, JV Fadeeva, WK Cullen, R Anwyl, MS Wolfe, ...
Nature 416 (6880), 535-539, 2002
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ...
Nature 398 (6727), 518-522, 1999
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
MS Wolfe, W Xia, BL Ostaszewski, TS Diehl, WT Kimberly, DJ Selkoe
Nature 398 (6727), 513-517, 1999
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
WT Kimberly, MJ LaVoie, BL Ostaszewski, W Ye, MS Wolfe, DJ Selkoe
Proceedings of the National Academy of Sciences 100 (11), 6382-6387, 2003
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
AP Weng, JM Millholland, Y Yashiro-Ohtani, ML Arcangeli, A Lau, C Wai, ...
Genes & development 20 (15), 2096-2109, 2006
The surface of articular cartilage contains a progenitor cell population
GP Dowthwaite, JC Bishop, SN Redman, IM Khan, P Rooney, DJR Evans, ...
Journal of cell science 117 (6), 889-897, 2004
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Y Miyamoto, A Maitra, B Ghosh, U Zechner, P Argani, ...
Cancer cell 3 (6), 565-576, 2003
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
WP Esler, WT Kimberly, BL Ostaszewski, TS Diehl, CL Moore, JY Tsai, ...
Nature cell biology 2 (7), 428-434, 2000
A portrait of Alzheimer secretases--new features and familiar faces
WP Esler, MS Wolfe
Science 293 (5534), 1449-1454, 2001
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling
AP Weng, Y Nam, MS Wolfe, WS Pear, JD Griffin, SC Blacklow, JC Aster
Molecular and cellular biology 23 (2), 655-664, 2003
Presenilin: running with scissors in the membrane
DJ Selkoe, MS Wolfe
Cell 131 (2), 215-221, 2007
Activity-dependent isolation of the presenilin–γ-secretase complex reveals nicastrin and a γ substrate
WP Esler, WT Kimberly, BL Ostaszewski, W Ye, TS Diehl, DJ Selkoe, ...
Proceedings of the National Academy of Sciences 99 (5), 2720-2725, 2002
Intramembrane proteolysis: theme and variations
MS Wolfe, R Kopan
Science 305 (5687), 1119-1123, 2004
Presenilins and γ-secretase: structure, function, and role in Alzheimer disease
B De Strooper, T Iwatsubo, MS Wolfe
Cold Spring Harbor perspectives in medicine 2 (1), a006304, 2012
Peptidomimetic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease
MS Wolfe, W Xia, CL Moore, DD Leatherwood, B Ostaszewski, T Rahmati, ...
Biochemistry 38 (15), 4720-4727, 1999
The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation
WT Kimberly, W Xia, T Rahmati, MS Wolfe, DJ Selkoe
Journal of Biological Chemistry 275 (5), 3173-3178, 2000
Substrate-targeting γ-secretase modulators
TL Kukar, TB Ladd, MA Bann, PC Fraering, R Narlawar, GM Maharvi, ...
Nature 453 (7197), 925-929, 2008
Cell surface presenilin-1 participates in the γ-secretase-like proteolysis of Notch
WJ Ray, M Yao, J Mumm, EH Schroeter, P Saftig, M Wolfe, DJ Selkoe, ...
Journal of Biological Chemistry 274 (51), 36801-36807, 1999
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
MA Leissring, MP Murphy, TR Mead, Y Akbari, MC Sugarman, ...
Proceedings of the National Academy of Sciences 99 (7), 4697-4702, 2002
Tumor necrosis factor-α, interleukin-1β, and interferon-γ stimulate γ-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
YF Liao, BJ Wang, HT Cheng, LH Kuo, MS Wolfe
Journal of Biological Chemistry 279 (47), 49523-49532, 2004
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