Raphael Kopan
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The canonical Notch signaling pathway: unfolding the activation mechanism
R Kopan, MXG Ilagan
Cell 137 (2), 216-233, 2009
29922009
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ...
Nature 398 (6727), 518-522, 1999
24371999
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
EH Schroeter, JA Kisslinger, R Kopan
Nature 393 (6683), 382-386, 1998
17821998
Signalling downstream of activated mammalian Notch
S Jarriault, C Brou, F Logeat, EH Schroeter, R Kopan, A Israel
Nature 377 (6547), 355-358, 1995
16151995
Notch signaling: from the outside in
JS Mumm, R Kopan
Developmental biology 228 (2), 151-165, 2000
11572000
A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
JS Mumm, EH Schroeter, MT Saxena, A Griesemer, X Tian, DJ Pan, ...
Molecular cell 5 (2), 197-206, 2000
9742000
NOTCH AND PRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration
D Selkoe, R Kopan
Annual review of neuroscience 26 (1), 565-597, 2003
7682003
γ-Secretase: proteasome of the membrane?
R Kopan, MXG Ilagan
Nature reviews Molecular cell biology 5 (6), 499-504, 2004
6462004
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
JS Lee, M Cella, KG McDonald, C Garlanda, GD Kennedy, M Nukaya, ...
Nature immunology 13 (2), 144-151, 2012
6032012
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
F Costantini, R Kopan
Developmental cell 18 (5), 698-712, 2010
5622010
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain
R Kopan, EH Schroeter, H Weintraub, JS Nye
Proceedings of the National Academy of Sciences 93 (4), 1683-1688, 1996
5591996
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
MJ Hilton, X Tu, X Wu, S Bai, H Zhao, T Kobayashi, HM Kronenberg, ...
Nature medicine 14 (3), 306-314, 2008
5422008
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
R Kopan, JS Nye, H Weintraub
Development 120 (9), 2385-2396, 1994
5401994
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro
DJ McCance, R Kopan, E Fuchs, LA Laimins
Proceedings of the National Academy of Sciences 85 (19), 7169-7173, 1988
4721988
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Y Tong, H Yamaguchi, E Giaime, S Boyle, R Kopan, RJ Kelleher, J Shen
Proceedings of the National Academy of Sciences 107 (21), 9879-9884, 2010
4582010
Intramembrane proteolysis: theme and variations
MS Wolfe, R Kopan
Science 305 (5687), 1119-1123, 2004
4152004
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.
A Stoler, R Kopan, M Duvic, E Fuchs
The Journal of cell biology 107 (2), 427-446, 1988
3941988
Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization.
R Kopan, G Traska, E Fuchs
The Journal of cell biology 105 (1), 427-440, 1987
3891987
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
QD Hu, BT Ang, M Karsak, WP Hu, XY Cui, T Duka, Y Takeda, W Chia, ...
Cell 115 (2), 163-175, 2003
3872003
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
SS Huppert, A Le, EH Schroeter, JS Mumm, MT Saxena, LA Milner, ...
Nature 405 (6789), 966-970, 2000
3872000
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