Raphael Kopan

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Ma. Xenia G. IlaganWashington UniversityEmail confirmado em wustl.edu
Eric H. SchroeterInstructor, Lakeview Technology AcademyEmail confirmado em kusd.edu
Alison GoateProfessor of Genetics & Genomic Sciences, Icahn School of Medicine at Mount SinaiEmail confirmado em mssm.edu
Jim RayWashington University, Merck, Envoy Therapeutics, Takeda, MD AndersonEmail confirmado em mdanderson.org
Jeff MummJohns Hopkins UniversityEmail confirmado em jhmi.edu
Michael WolfeProfessor of Medicinal Chemistry, University of KansasEmail confirmado em ku.edu
Bart De Stroopergewoon hoogleraar KU Leuven en onderzoeksdirecteur VIBEmail confirmado em cme.vib-kuleuven.be
Taisuke TomitaProfessor, Graduate School of Pharmaceutical Sciences, The University of TokyoEmail confirmado em mol.f.u-tokyo.ac.jp
Shuang ChenPfizerEmail confirmado em pfizer.com
Takeshi IwatsuboProfessor of Neuropathology, The University of TokyoEmail confirmado em m.u-tokyo.ac.jp
Paul SaftigProfessor of BiochemistryEmail confirmado em biochem.uni-kiel.de
Jeffrey NyeJohnson & Johnson Innovation, Janssen R&D, LLCEmail confirmado em its.jnj.com
Mustafa TurkozResearch FellowEmail confirmado em stanford.edu
Kameswaran SurendranSanford researchEmail confirmado em sanfordhealth.org
Mitsuru MorimotoRIKEN BDREmail confirmado em riken.jp
Chin-Tong OngTemasek Life Science LabEmail confirmado em tll.org.sg
Brandon HadlandFred Hutchinson Cancer Research Center, University of WashingtonEmail confirmado em fredhutch.org
Fanxin LongProfessor of Medicine and Developmental Biology, Orthopaedic Surgery, Washington University in StEmail confirmado em wustl.edu
Jeffrey H. MinerProf. of Medicine/Nephrology, Washington University School of Medicine in St. LouisEmail confirmado em wustl.edu
James Jonghyeob LeeCalico Life SciencesEmail confirmado em calicolabs.com

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Raphael Kopan

Cincinnati Children's Hospital Medical Center

Email confirmado em cchmc.org - Página inicial

Developmental Biology


Título Ordenar por citações Ordenar por ano Ordenar por título	Citado por Citado por	Ano
The canonical Notch signaling pathway: unfolding the activation mechanism R Kopan, MXG Ilagan Cell 137 (2), 216-233, 2009	3813	2009
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ... Nature 398 (6727), 518-522, 1999	2673	1999
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain EH Schroeter, JA Kisslinger, R Kopan Nature 393 (6683), 382-386, 1998	1986	1998
Signalling downstream of activated mammalian Notch S Jarriault, C Brou, F Logeat, EH Schroeter, R Kopan, A Israel Nature 377 (6547), 355-358, 1995	1772	1995
Notch signaling: from the outside in JS Mumm, R Kopan Developmental biology 228 (2), 151-165, 2000	1274	2000
A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1 JS Mumm, EH Schroeter, MT Saxena, A Griesemer, X Tian, DJ Pan, ... Molecular cell 5 (2), 197-206, 2000	1093	2000
NOTCH AND PRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration D Selkoe, R Kopan Annual review of neuroscience 26 (1), 565-597, 2003	842	2003
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch JS Lee, M Cella, KG McDonald, C Garlanda, GD Kennedy, M Nukaya, ... Nature immunology 13 (2), 144-151, 2012	790	2012
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development F Costantini, R Kopan Developmental cell 18 (5), 698-712, 2010	710	2010
γ-Secretase: proteasome of the membrane? R Kopan, MXG Ilagan Nature reviews Molecular cell biology 5 (6), 499-504, 2004	697	2004
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation MJ Hilton, X Tu, X Wu, S Bai, H Zhao, T Kobayashi, HM Kronenberg, ... Nature medicine 14 (3), 306-314, 2008	644	2008
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD R Kopan, JS Nye, H Weintraub Development 120 (9), 2385-2396, 1994	623	1994
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. R Kopan, EH Schroeter, H Weintraub, JS Nye Proceedings of the National Academy of Sciences 93 (4), 1683-1688, 1996	618	1996
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice Y Tong, H Yamaguchi, E Giaime, S Boyle, R Kopan, RJ Kelleher III, ... Proceedings of the National Academy of Sciences 107 (21), 9879-9884, 2010	543	2010
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. DJ McCance, R Kopan, E Fuchs, LA Laimins Proceedings of the National Academy of Sciences 85 (19), 7169-7173, 1988	521	1988
Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells L Pellegrinet, V Rodilla, Z Liu, S Chen, U Koch, L Espinosa, KH Kaestner, ... Gastroenterology 140 (4), 1230-1240. e7, 2011	474	2011
Intramembrane proteolysis: theme and variations MS Wolfe, R Kopan Science 305 (5687), 1119-1123, 2004	444	2004
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation QD Hu, BT Ang, M Karsak, WP Hu, XY Cui, T Duka, Y Takeda, W Chia, ... Cell 115 (2), 163-175, 2003	441	2003
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 SS Huppert, A Le, EH Schroeter, JS Mumm, MT Saxena, LA Milner, ... Nature 405 (6789), 966-970, 2000	423	2000
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens AT Satpathy, CG Briseño, JS Lee, D Ng, NA Manieri, W Kc, X Wu, ... Nature immunology 14 (9), 937-948, 2013	421	2013

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