| The canonical Notch signaling pathway: unfolding the activation mechanism R Kopan, MXG Ilagan Cell 137 (2), 216-233, 2009 | 2901 | 2009 |
| A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ... Nature 398 (6727), 518-522, 1999 | 2425 | 1999 |
| Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain EH Schroeter, JA Kisslinger, R Kopan Nature 393 (6683), 382-386, 1998 | 1766 | 1998 |
| Signalling downstream of activated mammalian Notch S Jarriault, C Brou, F Logeat, EH Schroeter, R Kopan, A Israel Nature 377 (6547), 355-358, 1995 | 1601 | 1995 |
| Notch signaling: from the outside in JS Mumm, R Kopan Developmental biology 228 (2), 151-165, 2000 | 1151 | 2000 |
| A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1 JS Mumm, EH Schroeter, MT Saxena, A Griesemer, X Tian, DJ Pan, ... Molecular cell 5 (2), 197-206, 2000 | 960 | 2000 |
| NOTCH AND PRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration D Selkoe, R Kopan Annual review of neuroscience 26 (1), 565-597, 2003 | 763 | 2003 |
| γ-Secretase: proteasome of the membrane? R Kopan, MXG Ilagan Nature reviews Molecular cell biology 5 (6), 499-504, 2004 | 640 | 2004 |
| AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch JS Lee, M Cella, KG McDonald, C Garlanda, GD Kennedy, M Nukaya, ... Nature immunology 13 (2), 144-151, 2012 | 586 | 2012 |
| Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain R Kopan, EH Schroeter, H Weintraub, JS Nye Proceedings of the National Academy of Sciences 93 (4), 1683-1688, 1996 | 554 | 1996 |
| Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development F Costantini, R Kopan Developmental cell 18 (5), 698-712, 2010 | 543 | 2010 |
| The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD R Kopan, JS Nye, H Weintraub Development 120 (9), 2385-2396, 1994 | 540 | 1994 |
| Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation MJ Hilton, X Tu, X Wu, S Bai, H Zhao, T Kobayashi, HM Kronenberg, ... Nature medicine 14 (3), 306-314, 2008 | 528 | 2008 |
| Human papillomavirus type 16 alters human epithelial cell differentiation in vitro DJ McCance, R Kopan, E Fuchs, LA Laimins Proceedings of the National Academy of Sciences 85 (19), 7169-7173, 1988 | 467 | 1988 |
| Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice Y Tong, H Yamaguchi, E Giaime, S Boyle, R Kopan, RJ Kelleher, J Shen Proceedings of the National Academy of Sciences 107 (21), 9879-9884, 2010 | 447 | 2010 |
| Intramembrane proteolysis: theme and variations MS Wolfe, R Kopan Science 305 (5687), 1119-1123, 2004 | 416 | 2004 |
| Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. A Stoler, R Kopan, M Duvic, E Fuchs The Journal of cell biology 107 (2), 427-446, 1988 | 389 | 1988 |
| Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. R Kopan, G Traska, E Fuchs The Journal of cell biology 105 (1), 427-440, 1987 | 384 | 1987 |
| Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 SS Huppert, A Le, EH Schroeter, JS Mumm, MT Saxena, LA Milner, ... Nature 405 (6789), 966-970, 2000 | 383 | 2000 |
| F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation QD Hu, BT Ang, M Karsak, WP Hu, XY Cui, T Duka, Y Takeda, W Chia, ... Cell 115 (2), 163-175, 2003 | 379 | 2003 |
Eric H. SchroeterInstructor, Lakeview Technology AcademyEmail confirmado em kusd.edu
