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Raphael Kopan
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The canonical Notch signaling pathway: unfolding the activation mechanism
R Kopan, MXG Ilagan
Cell 137 (2), 216-233, 2009
34362009
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ...
Nature 398 (6727), 518-522, 1999
25701999
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
EH Schroeter, JA Kisslinger, R Kopan
Nature 393 (6683), 382-386, 1998
19241998
Signalling downstream of activated mammalian Notch
S Jarriault, C Brou, F Logeat, EH Schroeter, R Kopan, A Israel
Nature 377 (6547), 355-358, 1995
17251995
Notch signaling: from the outside in
JS Mumm, R Kopan
Developmental biology 228 (2), 151-165, 2000
12292000
A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
JS Mumm, EH Schroeter, MT Saxena, A Griesemer, X Tian, DJ Pan, ...
Molecular cell 5 (2), 197-206, 2000
10502000
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration
D Selkoe, R Kopan
Annual review of neuroscience 26, 565, 2003
8092003
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
JS Lee, M Cella, KG McDonald, C Garlanda, GD Kennedy, M Nukaya, ...
Nature immunology 13 (2), 144-151, 2012
6972012
γ-Secretase: proteasome of the membrane?
R Kopan, M Ilagan, G Xenia
Nature reviews Molecular cell biology 5 (6), 499-504, 2004
6642004
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
F Costantini, R Kopan
Developmental cell 18 (5), 698-712, 2010
6432010
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.
R Kopan, EH Schroeter, H Weintraub, JS Nye
Proceedings of the National Academy of Sciences 93 (4), 1683-1688, 1996
6071996
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
R Kopan, JS Nye, H Weintraub
Development 120 (9), 2385-2396, 1994
6071994
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
MJ Hilton, X Tu, X Wu, S Bai, H Zhao, T Kobayashi, HM Kronenberg, ...
Nature medicine 14 (3), 306-314, 2008
6002008
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.
DJ McCance, R Kopan, E Fuchs, LA Laimins
Proceedings of the National Academy of Sciences 85 (19), 7169-7173, 1988
5191988
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Y Tong, H Yamaguchi, E Giaime, S Boyle, R Kopan, RJ Kelleher III, ...
Proceedings of the National Academy of Sciences 107 (21), 9879-9884, 2010
5082010
Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
L Pellegrinet, V Rodilla, Z Liu, S Chen, U Koch, L Espinosa, KH Kaestner, ...
Gastroenterology 140 (4), 1230-1240. e7, 2011
4302011
Intramembrane proteolysis: theme and variations
MS Wolfe, R Kopan
Science 305 (5687), 1119-1123, 2004
4302004
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
QD Hu, BT Ang, M Karsak, WP Hu, XY Cui, T Duka, Y Takeda, W Chia, ...
Cell 115 (2), 163-175, 2003
4262003
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
SS Huppert, A Le, EH Schroeter, JS Mumm, MT Saxena, LA Milner, ...
Nature 405 (6789), 966-970, 2000
4152000
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.
A Stoler, R Kopan, M Duvic, E Fuchs
The Journal of cell biology 107 (2), 427-446, 1988
4121988
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