Miguel C Seabra
Miguel C Seabra
CEDOC, NOVA Medical School, Universidade Nova de Lisboa
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Rab27a and Rab27b control different steps of the exosome secretion pathway
M Ostrowski, NB Carmo, S Krumeich, I Fanget, G Raposo, A Savina, ...
Nature cell biology 12 (1), 19-30, 2010
Protein Prenyltransferases (∗)
PJ Casey, MC Seabra
Journal of Biological Chemistry 271 (10), 5289-5292, 1996
Inhibition of purified p21ras farnesyl: protein transferase by Cys-AAX tetrapeptides
Y Reiss, JL Goldstein, MC Seabra, PJ Casey, MS Brown
Cell 62 (1), 81-88, 1990
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells
A Savina, C Jancic, S Hugues, P Guermonprez, P Vargas, IC Moura, ...
Cell 126 (1), 205-218, 2006
Evolution of the Rab family of small GTP-binding proteins
JB Pereira-Leal, MC Seabra
Journal of molecular biology 313 (4), 889-901, 2001
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial
RE MacLaren, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ...
The Lancet 383 (9923), 1129-1137, 2014
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
M Alexander, R Hu, MC Runtsch, DA Kagele, TL Mosbruger, ...
Nature communications 6 (1), 7321, 2015
Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression
A Bobrie, S Krumeich, F Reyal, C Recchi, LF Moita, MC Seabra, ...
Cancer research 72 (19), 4920-4930, 2012
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells
IS Okoye, SM Coomes, VS Pelly, S Czieso, V Papayannopoulos, ...
Immunity 41 (1), 89-103, 2014
Rab GTPases, intracellular traffic and disease
MC Seabra, EH Mules, AN Hume
Trends in molecular medicine 8 (1), 23-30, 2002
The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily
JB Pereira-Leal, MC Seabra
Journal of molecular biology 301 (4), 1077-1087, 2000
The melanosome: membrane dynamics in black and white
MS Marks, MC Seabra
Nature reviews Molecular cell biology 2 (10), 738-748, 2001
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria
B Önfelt, S Nedvetzki, RKP Benninger, MA Purbhoo, S Sowinski, ...
The Journal of Immunology 177 (12), 8476-8483, 2006
Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit
MC Seabra, Y Reiss, PJ Casey, MS Brown, JL Goldstein
Cell 65 (3), 429-434, 1991
Rab27a is required for regulated secretion in cytotoxic T lymphocytes
JC Stinchcombe, DC Barral, EH Mules, S Booth, AN Hume, LM Machesky, ...
The Journal of cell biology 152 (4), 825-834, 2001
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein
DA Andres, MC Seabra, MS Brown, SA Armstrong, TE Smeland, ...
Cell 73 (6), 1091-1099, 1993
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.
MC Seabra, JL Goldstein, TC Südhof, MS Brown
Journal of Biological Chemistry 267 (20), 14497-14503, 1992
GTPase activity of Rab5 acts as a timer for endocytic membrane fusion
V Rybin, O Ullrich, M Rubino, K Alexandrov, I Simon, MC Seabra, ...
Nature 383 (6597), 266-269, 1996
Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase
MC Seabra, MS Brown, JL Goldstein
Science 259 (5093), 377-381, 1993
Controlling the location and activation of Rab GTPases
MC Seabra, C Wasmeier
Current opinion in cell biology 16 (4), 451-457, 2004
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