Atsushi Takeda, M.D. & Ph.D.
Atsushi Takeda, M.D. & Ph.D.
Director, National Hospital Organization, Sendai-Nishitaga Hospital
Verified email at
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Oxidative damage is the earliest event in Alzheimer disease
A Nunomura, G Perry, G Aliev, K Hirai, A Takeda, EK Balraj, PK Jones, ...
Journal of Neuropathology & Experimental Neurology 60 (8), 759-767, 2001
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
W Satake, Y Nakabayashi, I Mizuta, Y Hirota, C Ito, M Kubo, T Kawaguchi, ...
Nature genetics 41 (12), 1303-1307, 2009
Role of mitochondrial dysfunction in Alzheimer's disease
R Castellani, K Hirai, G Aliev, KL Drew, A Nunomura, A Takeda, AD Cash, ...
Journal of neuroscience research 70 (3), 357-360, 2002
Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease
X Zhu, CA Rottkamp, H Boux, A Takeda, G Perry, MA Smith
Journal of neuropathology & experimental neurology 59 (10), 880-888, 2000
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases?
G Perry, A Nunomura, K Hirai, X Zhu, M Prez, J Avila, RJ Castellani, ...
Free Radical Biology and Medicine 33 (11), 1475-1479, 2002
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’hypothesis
X Zhu, RJ Castellani, A Takeda, A Nunomura, CS Atwood, G Perry, ...
Mechanisms of ageing and development 123 (1), 39-46, 2001
Tau phosphorylation in Alzheimer's disease: pathogen or protector?
H Lee, G Perry, PI Moreira, MR Garrett, Q Liu, X Zhu, A Takeda, ...
Trends in molecular medicine 11 (4), 164-169, 2005
Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation
G Perry, H Roder, A Nunomura, A Takeda, AL Friedlich, X Zhu, AK Raina, ...
Neuroreport 10 (11), 2411-2415, 1999
Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy
A Kikuchi, A Takeda, H Onodera, T Kimpara, K Hisanaga, N Sato, ...
Neurobiology of disease 9 (2), 244-248, 2002
Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study
T Baba, A Kikuchi, K Hirayama, Y Nishio, Y Hosokai, S Kanno, ...
Brain 135 (1), 161-169, 2012
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of τ induced by 4‐hydroxy‐2‐nonenal modification
A Takeda, MA Smith, J Avilá, A Nunomura, SL Siedlak, X Zhu, G Perry, ...
Journal of neurochemistry 75 (3), 1234-1241, 2000
Human oculocutaneous albinism caused by single base insertion in the tyrosinase gene
Y Tomita, A Takeda, S Okinaga, H Tagami, S Shibahara
Biochemical and biophysical research communications 164 (3), 990-996, 1989
Nucleic acid oxidation in Alzheimer disease
PI Moreira, A Nunomura, M Nakamura, A Takeda, JC Shenk, G Aliev, ...
Free Radical Biology and Medicine 44 (8), 1493-1505, 2008
Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau
A Takeda, G Perry, NG Abraham, BE Dwyer, RK Kutty, JT Laitinen, ...
Journal of Biological Chemistry 275 (8), 5395-5399, 2000
Challenging the amyloid cascade hypothesis: Senile plaques and amyloid‐β as protective adaptations to Alzheimer disease
HGON LEE, G Casadesus, X Zhu, A Takeda, G Perry, MA Smith
Annals of the New York Academy of Sciences 1019 (1), 1-4, 2004
Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease
T Kimpara, A Takeda, K Watanabe, Y Itoyama, S Ikawa, M Watanabe, ...
Human genetics 100, 145-147, 1997
Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group
I Stankovic, F Krismer, A Jesic, A Antonini, T Benke, RG Brown, DJ Burn, ...
Movement Disorders 29 (7), 857-867, 2014
Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease
MA Smith, A Nunomura, X Zhu, A Takeda, G Perry
Antioxidants and Redox Signaling 2 (3), 413-420, 2000
Cyclin'toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease
AK Raina, X Zhu, CA Rottkamp, M Monteiro, A Takeda, MA Smith
Journal of neuroscience research 61 (2), 128-133, 2000
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
E Miura, T Hasegawa, M Konno, M Suzuki, N Sugeno, N Fujikake, ...
Neurobiology of disease 71, 1-13, 2014
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