| Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A 2A receptor-dependent manner: A 2A … C Gomes, R Ferreira, J George, R Sanches, DI Rodrigues, N Gonçalves, ... Journal of neuroinflammation 10, 1-13, 2013 | 256 | 2013 |
| Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors S Viana da Silva, MG Haberl, P Zhang, P Bethge, C Lemos, N Gonçalves, ... Nature communications 7 (1), 11915, 2016 | 228 | 2016 |
| Depression as a glial-based synaptic dysfunction D Rial, C Lemos, H Pinheiro, JM Duarte, FQ Gonçalves, JI Real, ... Frontiers in cellular neuroscience 9, 521, 2016 | 182 | 2016 |
| Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory P Li, D Rial, PM Canas, JH Yoo, W Li, X Zhou, Y Wang, GJP van Westen, ... Molecular psychiatry 20 (11), 1339-1349, 2015 | 144 | 2015 |
| Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado–Joseph disease AT Simoes, N Gonçalves, A Koeppen, N Deglon, S Kügler, CB Duarte, ... Brain 135 (8), 2428-2439, 2012 | 142 | 2012 |
| Current challenges and emerging opportunities of CAR-T cell therapies TR Abreu, NA Fonseca, N Gonçalves, JN Moreira Journal of Controlled Release 319, 246-261, 2020 | 107 | 2020 |
| Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral‐based model of Machado–Joseph disease N Gonçalves, AT Simões, RA Cunha, LP de Almeida Annals of neurology 73 (5), 655-666, 2013 | 99 | 2013 |
| Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine FQ Gonçalves, JP Lopes, HB Silva, C Lemos, AC Silva, N Gonçalves, ... Neurobiology of Disease 132, 104570, 2019 | 89 | 2019 |
| Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory AP Simões, NJ Machado, N Gonçalves, MP Kaster, AT Simões, A Nunes, ... Neuropsychopharmacology 41 (12), 2862-2871, 2016 | 87 | 2016 |
| Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease AT Simões, N Gonçalves, RJ Nobre, C Bandeira Duarte, ... Human Molecular Genetics 23 (18), 4932-494, 2014 | 71 | 2014 |
| Neuronal adenosine A2A receptors are critical mediators of neurodegeneration triggered by convulsions PM Canas, LO Porciúncula, AP Simões, E Augusto, HB Silva, ... Eneuro 5 (6), 2018 | 56 | 2018 |
| Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado–Joseph disease J Duarte-Neves, N Gonçalves, J Cunha-Santos, AT Simões, ... Human molecular genetics 24 (19), 5451-5463, 2015 | 51 | 2015 |
| Cancer stem cells and nucleolin as drivers of carcinogenesis LS Carvalho, N Gonçalves, NA Fonseca, JN Moreira Pharmaceuticals 14 (1), 60, 2021 | 40 | 2021 |
| Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia N Gonçalves, AT Simoes, RD Prediger, H Hirai, RA Cunha, ... Annals of neurology 81 (3), 407-418, 2017 | 23 | 2017 |
| Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation S Alçada-Morais, N Gonçalves, V Moreno-Juan, B Andres, S Ferreira, ... Cerebral Cortex 31 (12), 5652-5663, 2021 | 20 | 2021 |
| Adenosine A2A receptors control synaptic remodeling in the adult brain X Xu, RO Beleza, FQ Gonçalves, S Valbuena, S Alçada-Morais, ... Scientific Reports 12 (1), 14690, 2022 | 16 | 2022 |
| Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction E Augusto, FQ Gonçalves, JE Real, HB Silva, D Pochmann, TS Silva, ... Neurobiology of Disease 157, 105441, 2021 | 16 | 2021 |
| Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making DT Leffa, P Pandolfo, N Gonçalves, NJ Machado, CM De Souza, JI Real, ... Frontiers in Molecular Neuroscience 11, 475, 2018 | 16 | 2018 |
| GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure NA Fonseca, AC Gregório, VM Mendes, R Lopes, T Abreu, N Gonçalves, ... Nano Today 37, 101095, 2021 | 15 | 2021 |
| Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors. Nat Commun 7: 11915 S Viana da Silva, MG Haberl, P Zhang, P Bethge, C Lemos, N Goncalves, ... | 15 | 2016 |
Luis Pereira de AlmeidaUniversity of Coimbra, CNC - Center for Neuroscience and Cell Biology & Faculty of Pharmacy & CIBBVerified email at cnc.uc.pt
