| ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets AJ Souers, JD Leverson, ER Boghaert, SL Ackler, ND Catron, J Chen, ... Nature medicine 19 (2), 202-208, 2013 | 3041 | 2013 |
| Regulation and functions of the IL-10 family of cytokines in inflammation and disease W Ouyang, S Rutz, NK Crellin, PA Valdez, SG Hymowitz Annual review of immunology 29, 71-109, 2011 | 2067 | 2011 |
| Therapeutic antibody targeting of individual Notch receptors Y Wu, C Cain-Hom, L Choy, TJ Hagenbeek, GP De Leon, Y Chen, ... Nature 464 (7291), 1052-1057, 2010 | 843 | 2010 |
| IL‐17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL‐17F, and implications for receptor binding SG Hymowitz, EH Filvaroff, JP Yin, J Lee, L Cai, P Risser, M Maruoka, ... The EMBO journal, 2001 | 703 | 2001 |
| Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL KW Wagner, EA Punnoose, T Januario, DA Lawrence, RM Pitti, ... Nature medicine 13 (9), 1070-1077, 2007 | 701 | 2007 |
| Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies K Newton, ML Matsumoto, IE Wertz, DS Kirkpatrick, JR Lill, J Tan, ... Cell 134 (4), 668-678, 2008 | 653 | 2008 |
| Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5 SG Hymowitz, HW Christinger, G Fuh, M Ultsch, M O'Connell, RF Kelley, ... Molecular cell 4 (4), 563-571, 1999 | 602 | 1999 |
| The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity SA Gillmor, A Villaseñor, R Fletterick, E Sigal, MF Browner Nature structural biology 4 (12), 1003-1009, 1997 | 586 | 1997 |
| K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody ML Matsumoto, KE Wickliffe, KC Dong, C Yu, I Bosanac, D Bustos, L Phu, ... Molecular cell 39 (3), 477-484, 2010 | 466 | 2010 |
| Loss of the tumor suppressor BAP1 causes myeloid transformation A Dey, D Seshasayee, R Noubade, DM French, J Liu, MS Chaurushiya, ... Science 337 (6101), 1541-1546, 2012 | 431 | 2012 |
| Specific Btk inhibition suppresses B cell–and myeloid cell–mediated arthritis JA Di Paolo, T Huang, M Balazs, J Barbosa, KH Barck, BJ Bravo, ... Nature chemical biology 7 (1), 41-50, 2011 | 382 | 2011 |
| Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors M Yan, LC Wang, SG Hymowitz, S Schilbach, J Lee, A Goddard, ... Science 290 (5491), 523-527, 2000 | 379 | 2000 |
| A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL SG Hymowitz, MP O'Connell, MH Ultsch, A Hurst, K Totpal, A Ashkenazi, ... Biochemistry 39 (4), 633-640, 2000 | 357 | 2000 |
| An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells NS Wilson, B Yang, A Yang, S Loeser, S Marsters, D Lawrence, Y Li, ... Cancer cell 19 (1), 101-113, 2011 | 340 | 2011 |
| Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than … RF Kelley, K Totpal, SH Lindstrom, M Mathieu, K Billeci, L DeForge, R Pai, ... Journal of Biological Chemistry 280 (3), 2205-2212, 2005 | 325 | 2005 |
| Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ... ACS medicinal chemistry letters 5 (10), 1088-1093, 2014 | 307 | 2014 |
| A20: from ubiquitin editing to tumour suppression SG Hymowitz, IE Wertz Nature Reviews Cancer 10 (5), 332-341, 2010 | 292 | 2010 |
| Molecular recognition by a binary code FA Fellouse, B Li, DM Compaan, AA Peden, SG Hymowitz, SS Sidhu Journal of molecular biology 348 (5), 1153-1162, 2005 | 288 | 2005 |
| Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152) JA Flygare, M Beresini, N Budha, H Chan, IT Chan, S Cheeti, F Cohen, ... Journal of medicinal chemistry 55 (9), 4101-4113, 2012 | 266 | 2012 |
| Interactions between Hedgehog proteins and their binding partners come into view PA Beachy, SG Hymowitz, RA Lazarus, DJ Leahy, C Siebold Genes & development 24 (18), 2001-2012, 2010 | 261 | 2010 |
