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Philip Tedeschi
Philip Tedeschi
Verified email at rutgers.edu
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Year
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
PM Tedeschi, EK Markert, M Gounder, H Lin, D Dvorzhinski, SC Dolfi, ...
Cell death & disease 4 (10), e877-e877, 2013
2762013
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates
SC Dolfi, LLY Chan, J Qiu, PM Tedeschi, JR Bertino, KM Hirshfield, ...
Cancer & metabolism 1, 1-13, 2013
1832013
Overexpression of the mitochondrial folate and glycine–serine pathway: a new determinant of methotrexate selectivity in tumors
A Vazquez, PM Tedeschi, JR Bertino
Cancer research 73 (2), 478-482, 2013
882013
Mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) overexpression is associated with tumor cell proliferation and is a novel target for drug development
PM Tedeschi, A Vazquez, JE Kerrigan, JR Bertino
Molecular Cancer Research 13 (10), 1361-1366, 2015
752015
NAD+ Kinase as a Therapeutic Target in Cancer
PM Tedeschi, N Bansal, JE Kerrigan, EE Abali, KW Scotto, JR Bertino
Clinical cancer research 22 (21), 5189-5195, 2016
702016
Functional annotation of rare gene aberration drivers of pancreatic cancer
YH Tsang, T Dogruluk, PM Tedeschi, J Wardwell-Ozgo, H Lu, M Espitia, ...
Nature communications 7 (1), 10500, 2016
632016
In cancer, all roads lead to NADPH
GM Rather, AA Pramono, Z Szekely, JR Bertino, PM Tedeschi
Pharmacology & therapeutics 226, 107864, 2021
412021
Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs
YC Hsieh, P Tedeschi, RAB Lawal, D Banerjee, K Scotto, JE Kerrigan, ...
Molecular pharmacology 83 (2), 339-353, 2013
322013
Suppression of cytosolic NADPH pool by thionicotinamide increases oxidative stress and synergizes with chemotherapy
PM Tedeschi, HX Lin, M Gounder, JE Kerrigan, EE Abali, K Scotto, ...
Molecular pharmacology 88 (4), 720-727, 2015
282015
Quantification of folate metabolism using transient metabolic flux analysis
PM Tedeschi, N Johnson-Farley, H Lin, LM Shelton, T Ooga, G Mackay, ...
Cancer & metabolism 3, 1-14, 2015
222015
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts
PM Tedeschi, YK Kathari, IN Farooqi, JR Bertino
Cancer chemotherapy and pharmacology 74, 1029-1032, 2014
172014
MTHFD2-a new twist?
PM Tedeschi, KW Scotto, J Kerrigan, JR Bertino
Oncotarget 7 (7), 7368, 2016
82016
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell Death Dis 2013; 4: e877
PM Tedeschi
62013
The castrate resistant PC-3 cell line with neuroendocrine features is enriched in tumor initiating cells and is resistant to enzalutamide and abiraterone but sensitive to …
N Bansal, L Wu, NJ Farley, P Tedeschi, JR Bertino
Cancer Research 75 (15_Supplement), 4208-4208, 2015
22015
Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination
PM Tedeschi, YK Kathari, N Johnson-Farley, JR Bertino
Cancer chemotherapy and pharmacology 75, 1247-1252, 2015
22015
Cell proliferation and tissue remodeling are major determinants of cancer metabolism and the response to drugs targeting metabolism
E Markert, P Tedeschi, S Dolphi, K Hirshfield, J Bertino, Z Oltvai, ...
Cancer & Metabolism 2, 1-1, 2014
12014
Abstract PR06: Functional prioritization of rare gene aberration drivers of cancer
K Scott, YH Tsang, T Dogruluk, P Tedeschi, J Bertino, G Mills
Cancer Research 75 (22_Supplement_1), PR06-PR06, 2015
2015
Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination
PM Tedeschi, YK Kathari, I Farooqi, JR Bertino
Cancer Research 74 (19_Supplement), 843-843, 2014
2014
Abstract C151: Contribution of serine, folate, and glycine metabolism to the ATP, NADPH, and purine requirements of cancer cells.
PM Tedeschi, EK Markert, M Gounder, HX Lin, SC Dolfi, LLY Chan, J Qiu, ...
Molecular Cancer Therapeutics 12 (11_Supplement), C151-C151, 2013
2013
Abstract A266: Leucovorin rescue of high dose pralatrexate in mesothelioma xenografts.
PM Tedeschi, I Farooqi, Y Kathari, JR Bertino
Molecular Cancer Therapeutics 12 (11_Supplement), A266-A266, 2013
2013
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