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Marcelo A. Lima
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Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin
CJ Mycroft-West, D Su, I Pagani, TR Rudd, S Elli, NS Gandhi, ...
Thrombosis and haemostasis 120 (12), 1700-1715, 2020
499*2020
Heparan sulfate and heparin interactions with proteins
MCZ Meneghetti, AJ Hughes, TR Rudd, HB Nader, AK Powell, EA Yates, ...
Journal of the Royal Society Interface 12 (110), 20150589, 2015
2792015
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
S Ghezzi, L Cooper, A Rubio, I Pagani, MR Capobianchi, G Ippolito, ...
Antiviral research 140, 13-17, 2017
1002017
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations
JA Tree, JE Turnbull, KR Buttigieg, MJ Elmore, N Coombes, J Hogwood, ...
British Journal of Pharmacology 178 (3), 626-635, 2021
922021
Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp
AS Brito, DS Arimatéia, LR Souza, MA Lima, VO Santos, VP Medeiros, ...
Bioorganic & medicinal chemistry 16 (21), 9588-9595, 2008
882008
New applications of heparin and other glycosaminoglycans
M Lima, T Rudd, E Yates
Molecules 22 (5), 749, 2017
862017
Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction
SE Guimond, CJ Mycroft-West, NS Gandhi, JA Tree, TT Le, CM Spalluto, ...
ACS central science 8 (5), 527-545, 2022
81*2022
Atomic details of the interactions of glycosaminoglycans with amyloid-β fibrils
KL Stewart, E Hughes, EA Yates, GR Akien, TY Huang, MA Lima, ...
Journal of the American Chemical Society 138 (27), 8328-8331, 2016
512016
A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential
AS Brito, RS Cavalcante, LCGF Palhares, AJ Hughes, GPV Andrade, ...
Carbohydrate polymers 99, 372-378, 2014
482014
Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain
ZP Schuurs, E Hammond, S Elli, TR Rudd, CJ Mycroft-West, MA Lima, ...
Computational and Structural Biotechnology Journal 19, 2806-2818, 2021
432021
A heparin mimetic isolated from a marine shrimp suppresses neovascularization
JL Dreyfuss, CV Regatieri, MA Lima, EJ Paredes‐gamero, AS Brito, ...
Journal of Thrombosis and Haemostasis 8 (8), 1828-1837, 2010
422010
Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan
RP Cavalheiro, MA Lima, TR Jarrouge-Bouças, GM Viana, CC Lopes, ...
Matrix Biology 63, 23-37, 2017
412017
The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models
SP Davies, CJ Mycroft-West, I Pagani, HJ Hill, Z Stamataki, MA De Lima, ...
Frontiers in Pharmacology 12, 660490, 2021
402021
SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells
CM Vicente, MA Lima, HB Nader, L Toma
Journal of Experimental & Clinical Cancer Research 34, 1-16, 2015
402015
A heparin-like compound isolated from a marine crab rich in glucuronic acid 2-O-sulfate presents low anticoagulant activity
GPV Andrade, MA Lima, AA de Souza Junior, J Fareed, DA Hoppensteadt, ...
Carbohydrate polymers 94 (1), 647-654, 2013
392013
A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence
SF Chavante, AS Brito, M Lima, E Yates, H Nader, M Guerrini, G Torri, ...
Carbohydrate research 390, 59-66, 2014
382014
A new approach for heparin standardization: Combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis
MA Lima, TR Rudd, EHC de Farias, LF Ebner, TF Gesteira, LM de Souza, ...
PLoS One 6 (1), e15970, 2011
362011
Lepstospira interrogans shotgun phage display identified LigB as a heparin-binding protein
ATC Ching, RD Fávaro, SS Lima, AAM Chaves, MA de Lima, HB Nader, ...
Biochemical and biophysical research communications 427 (4), 774-779, 2012
332012
Active site mapping of Loxosceles phospholipases D: Biochemical and biological features
L Vuitika, D Chaves-Moreira, I Caruso, MA Lima, FH Matsubara, ...
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2016
322016
Enhanced tumorigenic potential of colorectal cancer cells by extracellular sulfatases
CM Vicente, MA Lima, EA Yates, HB Nader, L Toma
Molecular Cancer Research 13 (3), 510-523, 2015
312015
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