| Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version … YW Chen, CPB Yiu, KY Wong F1000Research 9, 129, 2020 | 515 | 2020 |
| Structure of UreG/UreF/UreH complex reveals how urease accessory proteins facilitate maturation of Helicobacter pylori urease YH Fong, HC Wong, MH Yuen, PH Lau, YW Chen, KB Wong PLoS biology 11 (10), e1001678, 2013 | 131 | 2013 |
| Rational design of a novel fluorescent biosensor for β-lactam antibiotics from a class A β-lactamase PH Chan, HB Liu, YW Chen, KC Chan, CW Tsang, YC Leung, KY Wong Journal of the American Chemical Society 126 (13), 4074-4075, 2004 | 93 | 2004 |
| Contribution of Buried Hydrogen Bonds to Protein Stability The Crystal Structures of Two Barnase Mutants YW Chen, AR Fersht, K Henrick Journal of molecular biology 234 (4), 1158-1170, 1993 | 92 | 1993 |
| Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir HS Lo, KPY Hui, HM Lai, X He, KS Khan, S Kaur, J Huang, Z Li, ... ACS central science 7 (5), 792-802, 2021 | 81 | 2021 |
| Crystal structure of a dimeric chymotrypsin inhibitor 2 mutant containing an inserted glutamine repeat YW Chen, K Stott, MF Perutz Proceedings of the National Academy of Sciences 96 (4), 1257-1261, 1999 | 80 | 1999 |
| The structure of the AXH domain of spinocerebellar ataxin-1 YW Chen, MD Allen, DB Veprintsev, J Löwe, M Bycroft Journal of Biological Chemistry 279 (5), 3758-3765, 2004 | 72 | 2004 |
| Assembly of Preactivation Complex for Urease Maturation in Helicobacter pylori CRYSTAL STRUCTURE OF UreF-UreH PROTEIN COMPLEX YH Fong, HC Wong, CP Chuck, YW Chen, H Sun, KB Wong Journal of Biological Chemistry 286 (50), 43241-43249, 2011 | 60 | 2011 |
| Does NMR mean “not for molecular replacement”? Using NMR-based search models to solve protein crystal structures YW Chen, EJ Dodson, GJ Kleywegt Structure 8 (11), R213-R220, 2000 | 56 | 2000 |
| Structure of the C-terminal sterile α-motif (SAM) domain of human p73α WK Wang, M Bycroft, NW Foster, AM Buckle, AR Fersht, YW Chen Acta Crystallographica Section D: Biological Crystallography 57 (4), 545-551, 2001 | 49 | 2001 |
| First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A* 01 complexed with two immunogenic SIV epitopes and insights into CTL escape F Chu, Z Lou, YW Chen, Y Liu, B Gao, L Zong, AH Khan, JI Bell, Z Rao, ... The Journal of Immunology 178 (2), 944-952, 2007 | 40 | 2007 |
| Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing WNV Chow, JCK Ngo, W Li, YW Chen, KMV Tam, HYE Chan, CCJ Miller, ... Biochemical Journal 470 (3), 303-317, 2015 | 35 | 2015 |
| Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction YS Tang, S Xu, YW Chen, JH Wang, PC Shaw Nucleic Acids Research 49 (7), 4144-4154, 2021 | 28 | 2021 |
| Self-Assembly and Conformational Heterogeneity of the AXH Domain of Ataxin-1: An Unusual Example of a Chameleon Fold C de Chiara, M Rees, RP Menon, K Pauwels, C Lawrence, PV Konarev, ... Biophysical journal 104 (6), 1304-1313, 2013 | 26 | 2013 |
| Solution solution: using NMR models for molecular replacement YW Chen Acta Crystallographica Section D: Biological Crystallography 57 (10), 1457-1461, 2001 | 25 | 2001 |
| Crystal structure of ribosomal protein L30e from the extreme thermophile Thermococcus celer: thermal stability and RNA binding YW Chen, M Bycroft, KB Wong Biochemistry 42 (10), 2857-2865, 2003 | 21 | 2003 |
| Conformational dynamics of the helix 10 region as an allosteric site in class A β-lactamase inhibitory binding L Huang, PK So, YW Chen, YC Leung, ZP Yao Journal of the American Chemical Society 142 (32), 13756-13767, 2020 | 20 | 2020 |
| Solution Model of the Intrinsically Disordered Polyglutamine Tract-Binding Protein-1 M Rees, C Gorba, C de Chiara, TTT Bui, M Garcia-Maya, AF Drake, ... Biophysical journal 102 (7), 1608-1616, 2012 | 20 | 2012 |
| Solution structure and thermal stability of ribosomal protein L30e from hyperthermophilic archaeon Thermococcus celer KB Wong, CF Lee, SH Chan, TY Leung, YW Chen, M Bycroft Protein science 12 (7), 1483-1495, 2003 | 20 | 2003 |
| A systematic case study on using NMR models for molecular replacement: p53 tetramerization domain revisited YW Chen, GM Clore Acta Crystallographica Section D: Biological Crystallography 56 (12), 1535-1540, 2000 | 19 | 2000 |
Kam-Bo WONGProfessor, School of Life Sciences, The Chinese University of Hong KongVerified email at cuhk.edu.hk
