| Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins RD Cramer, DE Patterson, JD Bunce Journal of the American Chemical Society 110 (18), 5959-5967, 1988 | 3558 | 1988 |
| Validation of the general purpose tripos 5.2 force field M Clark, RD Cramer III, N Van Opdenbosch Journal of computational chemistry 10 (8), 982-1012, 1989 | 3323 | 1989 |
| QSAR modeling: where have you been? Where are you going to? A Cherkasov, EN Muratov, D Fourches, A Varnek, II Baskin, M Cronin, ... Journal of medicinal chemistry 57 (12), 4977-5010, 2014 | 1859 | 2014 |
| Effect of shape on binding of steroids to carrier proteins RD Cramer, DE Patterson, JD Bunce J. Am. Chem. Soc 110, 5959-5967, 1988 | 1766 | 1988 |
| Crossvalidation, bootstrapping, and partial least squares compared with multiple regression in conventional QSAR studies RD Cramer III, JD Bunce, DE Patterson, IE Frank Quantitative Structure‐Activity Relationships 7 (1), 18-25, 1988 | 1146 | 1988 |
| Neighborhood behavior: a useful concept for validation of “molecular diversity” descriptors DE Patterson, RD Cramer, AM Ferguson, RD Clark, LE Weinberger Journal of medicinal chemistry 39 (16), 3049-3059, 1996 | 632 | 1996 |
| The probability of chance correlation using partial least squares (PLS) M Clark, RD Cramer III Quantitative Structure‐Activity Relationships 12 (2), 137-145, 1993 | 376 | 1993 |
| Di‐μ‐chlorotetrakis (ethylene) dirhodium (I), 2, 4‐Pentanedionatobis (ethylene) rhodium (I), and Di‐μ‐chlorotetracarbonyldirhodium (I) R Cramer, JA McCleverty, J Bray Inorganic Syntheses 15, 14-18, 1974 | 303 | 1974 |
| Partial least squares (PLS): its strengths and limitations RD Cramer III Perspectives in drug discovery and design 1 (2), 269-278, 1993 | 287 | 1993 |
| Comparative molecular field analysis (CoMFA). 2. Toward its use with 3D-structural databases M Clark, RD Cramer III, DM Jones, DE Patterson, PE Simeroth Tetrahedron Computer Methodology 3 (1), 47-59, 1990 | 253 | 1990 |
| Topomer CoMFA: a design methodology for rapid lead optimization RD Cramer Journal of medicinal chemistry 46 (3), 374-388, 2003 | 244 | 2003 |
| Substructural analysis. Novel approach to the problem of drug design RD Cramer III, G Redl, CE Berkoff Journal of Medicinal Chemistry 17 (5), 533-535, 1974 | 230 | 1974 |
| BC (DEF) parameters. 1. The intrinsic dimensionality of intermolecular interactions in the liquid state RD Cramer III Journal of the American Chemical Society 102 (6), 1837-1849, 1980 | 187 | 1980 |
| The developing practice of comparative molecular field analysis RD Cramer III, SA DePriest, DE Patterson, P Hecht 3D QSAR in drug design: Theory, methods and applications, 443-485, 1993 | 185 | 1993 |
| Bioisosterism as a molecular diversity descriptor: Steric fields of single “topomeric” conformers RD Cramer, RD Clark, DE Patterson, AM Ferguson Journal of medicinal chemistry 39 (16), 3060-3069, 1996 | 175 | 1996 |
| 111 & Van Opdenbosch, N.(1989) M Clark, RD Cramer J. Com~ putarionai Chem 10, 982-1012, 0 | 170 | |
| Three-dimensional structure-activity relationships GR Marshall, RD Cramer III Trends in pharmacological sciences 9 (8), 285-289, 1988 | 168 | 1988 |
| JD Bunce Comparative Molecular Field Analysis (CoMFA). 1 RD Cramer, DE Patterson Effect of shape on binding of steroids to carrier proteins 110, 5959-5967, 1988 | 157 | 1988 |
| Computer-assisted synthetic analysis. Facile man-machine communication of chemical structure by interactive computer graphics EJ Corey, WT Wipke, RD Cramer III, WJ Howe Journal of the American Chemical Society 94 (2), 421-430, 1972 | 152 | 1972 |
| “Lead hopping”. Validation of topomer similarity as a superior predictor of similar biological activities RD Cramer, RJ Jilek, S Guessregen, SJ Clark, B Wendt, RD Clark Journal of medicinal chemistry 47 (27), 6777-6791, 2004 | 139 | 2004 |
