| Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease I Nascimento-Ferreira, T Santos-Ferreira, L Sousa-Ferreira, G Auregan, ... Brain 134 (5), 1400-1415, 2011 | 221 | 2011 |
| Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice C Nóbrega, I Nascimento-Ferreira, I Onofre, D Albuquerque, H Hirai, ... PloS one 8 (1), e52396, 2013 | 137 | 2013 |
| Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado–Joseph disease I Nascimento-Ferreira, C Nobrega, A Vasconcelos-Ferreira, I Onofre, ... Brain 136 (7), 2173-2188, 2013 | 109 | 2013 |
| Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment I Onofre, N Mendonça, S Lopes, R Nobre, JB de Melo, IM Carreira, ... Scientific reports 6 (1), 28220, 2016 | 81 | 2016 |
| Unravelling endogenous microRNA system dysfunction as a new pathophysiological mechanism in Machado-Joseph disease V Carmona, J Cunha-Santos, I Onofre, AT Simões, U Vijayakumar, ... Molecular Therapy 25 (4), 1038-1055, 2017 | 52 | 2017 |
| Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology C Nóbrega, I Nascimento-Ferreira, I Onofre, D Albuquerque, M Conceição, ... The Cerebellum 12, 441-455, 2013 | 45 | 2013 |
| RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease C Nobrega, I Nascimento-Ferreira, I Onofre, D Albuquerque, N Deglon, ... PLoS One 9 (8), e100086, 2014 | 42 | 2014 |
| Mitochondrial and redox modifications in huntington disease induced pluripotent stem cells rescued by CRISPR/Cas9 CAGs targeting C Lopes, Y Tang, SI Anjo, B Manadas, I Onofre, LP de Almeida, GQ Daley, ... Frontiers in cell and developmental biology 8, 576592, 2020 | 29 | 2020 |
| Loss of hierarchical imprinting regulation at the Prader–Willi/Angelman syndrome locus in human iPSCs D Pólvora-Brandão, M Joaquim, I Godinho, D Aprile, AR Álvaro, I Onofre, ... Human molecular genetics 27 (23), 3999-4011, 2018 | 26 | 2018 |
| Stem cell-based therapies for polyglutamine diseases LS Mendonça, I Onofre, CO Miranda, R Perfeito, C Nóbrega, ... Polyglutamine Disorders, 439-466, 2018 | 15 | 2018 |
| Dissecting the pathogenesis of Machado-Joseph Disease in a new human disease model derived from induced pluripotent stem cells IMS Onofre 00500:: Universidade de Coimbra, 2016 | 3 | 2016 |
| Protocol for the characterization of the cytosine-adenine-guanine tract and flanking polymorphisms in Machado-Joseph disease: impact on diagnosis and development of gene-based … SM Lopes, R Faro, MM Lopes, I Onofre, N Mendonça, J Ribeiro, ... The Journal of Molecular Diagnostics 22 (6), 782-793, 2020 | 1 | 2020 |
| Nuclear aging in polyglutamine-induced neurodegeneration D Pereira, J Cunha-Santos, A Vasconcelos-Ferreira, J Duarte-Neves, ... bioRxiv, 2023.06. 09.544056, 2023 | | 2023 |
| RNA Interference Mitigates Motor and Neuropathological Deficits in C Nóbrega, I Nascimento-Ferreira, I Onofre, D Albuquerque, N Déglon | | 2014 |
| Silencing of mutant ataxin-3 rescues motor deficits and neurological abnormalities in Machado-Joseph disease transgenic mice C Nobrega, I Nascimento-Ferreira, I Onofre, D Albuquerque, H Hirai, ... HUMAN GENE THERAPY 22 (10), A35-A35, 2011 | | 2011 |
| XVIII Annual Congress of the European Society of Gene and Cell Therapy (ESGCT) October 22–25, 2010 Milan, Italy T Cathomen, T VandenDriessche, A Aartsma-Rus, GJB van Ommen, ... Human Gene Therapy, 1357-1499, 2010 | | 2010 |
| Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease I Nascimento-Ferreira, C Nobrega, I Onofre, N Deglon, LP de Almeida HUMAN GENE THERAPY 21 (10), 1426-1426, 2010 | | 2010 |
| Protocol for the Characterization of the CAG Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies SM Lopes, R Faro, MM Lopes, I Onofre, N Mendonça, J Ribeiro, ... | | |
Luis Pereira de AlmeidaUniversity of Coimbra, CNC - Center for Neuroscience and Cell Biology & Faculty of Pharmacy & CIBBVerified email at cnc.uc.pt
