Svend Kjaer
Svend Kjaer
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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
H Plun-Favreau, K Klupsch, N Moisoi, S Gandhi, S Kjaer, D Frith, ...
Nature cell biology 9 (11), 1243-1252, 2007
PINK1 cleavage at position A103 by the mitochondrial protease PARL
E Deas, H Plun-Favreau, S Gandhi, H Desmond, S Kjaer, SHY Loh, ...
Human molecular genetics 20 (5), 867-879, 2011
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
KW Ng, N Faulkner, GH Cornish, A Rosa, R Harvey, S Hussain, R Ulferts, ...
Science 370 (6522), 1339-1343, 2020
F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells
S Ahrens, S Zelenay, D Sancho, P Hanč, S Kjr, C Feest, G Fletcher, ...
Immunity 36 (4), 635-645, 2012
Structure and chemical inhibition of the RET tyrosine kinase domain
PP Knowles, J Murray-Rust, S Kjr, RP Scott, S Hanrahan, M Santoro, ...
Journal of biological chemistry 281 (44), 33577-33587, 2006
Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site
J Anders, S Kjr, CF Ibez
Journal of Biological Chemistry 276 (38), 35808-35817, 2001
A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome
AC Simon, JC Zhou, RL Perera, F van Deursen, C Evrin, ME Ivanova, ...
Nature 510 (7504), 293-297, 2014
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
CF Houlihan, N Vora, T Byrne, D Lewer, G Kelly, J Heaney, S Gandhi, ...
The Lancet 396 (10246), e6-e7, 2020
Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN
J Stingele, R Bellelli, F Alte, G Hewitt, G Sarek, SL Maslen, SE Tsutakawa, ...
Molecular cell 64 (4), 688-703, 2016
Isoform diversity in the Arp2/3 complex determines actin filament dynamics
JVG Abella, C Galloni, J Pernier, DJ Barry, S Kjr, MF Carlier, M Way
Nature cell biology 18 (1), 76-86, 2016
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins
P Riou, S Kjr, R Garg, A Purkiss, R George, RJ Cain, G Bineva, ...
Cell 153 (3), 640-653, 2013
Synthesis, structure–activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors
L Mologni, R Rostagno, S Brussolo, PP Knowles, S Kjaer, J Murray-Rust, ...
Bioorganic & medicinal chemistry 18 (4), 1482-1496, 2010
Identification of a surface for binding to the GDNF-GFRα1 complex in the first cadherin-like domain of RET
S Kjr, CF Ibez
Journal of Biological Chemistry 278 (48), 47898-47904, 2003
Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET
S Kjr, CF Ibanez
Human molecular genetics 12 (17), 2133-2144, 2003
The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells
AG Van der Veen, PV Maillard, JM Schmidt, SA Lee, S Deddouche‐Grass, ...
The EMBO journal 37 (4), e97479, 2018
Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations
S Kjaer, K Kurokawa, M Perrinjaquet, C Abrescia, CF Ibanez
Oncogene 25 (53), 7086-7095, 2006
RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association
KM Goodman, S Kjr, F Beuron, PP Knowles, A Nawrotek, EM Burns, ...
Cell reports 8 (6), 1894-1904, 2014
Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens
P Hanč, T Fujii, S Iborra, Y Yamada, J Huotari, O Schulz, S Ahrens, S Kjr, ...
Immunity 42 (5), 839-849, 2015
Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen
CR Willcox, P Vantourout, M Salim, I Zlatareva, D Melandri, L Zanardo, ...
Immunity 51 (5), 813-825. e4, 2019
Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes
S Kjr, M Linch, A Purkiss, B Kostelecky, PP Knowles, C Rosse, P Riou, ...
Biochemical journal 451 (2), 329-342, 2013
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