Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence E Sapey, H Greenwood, G Walton, E Mann, A Love, N Aaronson, ... Blood, The Journal of the American Society of Hematology 123 (2), 239-248, 2014 | 360 | 2014 |
Understanding the role of neutrophils in chronic inflammatory airway disease AE Jasper, WJ McIver, E Sapey, GM Walton F1000Research 8, 2019 | 166 | 2019 |
Simvastatin improves neutrophil function and clinical outcomes in pneumonia. A pilot randomized controlled clinical trial E Sapey, JM Patel, H Greenwood, GM Walton, F Grudzinska, D Parekh, ... American journal of respiratory and critical care medicine 200 (10), 1282-1293, 2019 | 101 | 2019 |
Pulmonary infections in the elderly lead to impaired neutrophil targeting, which is improved by simvastatin E Sapey, JM Patel, HL Greenwood, GM Walton, J Hazeldine, C Sadhra, ... American journal of respiratory and critical care medicine 196 (10), 1325-1336, 2017 | 89 | 2017 |
Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: the neutrophil as an immunotherapeutic target JA Stockley, GM Walton, JM Lord, E Sapey International immunopharmacology 17 (4), 1211-1217, 2013 | 76 | 2013 |
Neutrophilic inflammation in the pathogenesis of chronic obstructive pulmonary disease A Butler, GM Walton, E Sapey COPD: Journal of Chronic Obstructive Pulmonary Disease 15 (4), 392-404, 2018 | 63 | 2018 |
Repurposing treatments to enhance innate immunity. Can statins improve neutrophil functions and clinical outcomes in COPD? GM Walton, JA Stockley, D Griffiths, CS Sadhra, T Purvis, E Sapey Journal of clinical medicine 5 (10), 89, 2016 | 59 | 2016 |
The clinical and inflammatory relationships between periodontitis and chronic obstructive pulmonary disease E Sapey, Z Yonel, R Edgar, S Parmar, S Hobbins, P Newby, D Crossley, ... Journal of clinical periodontology 47 (9), 1040-1052, 2020 | 47 | 2020 |
Statin therapy in patients with community-acquired pneumonia FS Grudzinska, DPS Dosanjh, D Parekh, RCA Dancer, J Patel, ... Clinical Medicine 17 (5), 403, 2017 | 38 | 2017 |
Neutrophil extracellular traps (NETs) in COPD: A potential novel mechanism for host damage in acute exacerbations J Pullan, H Greenwood, GM Walton, RA Stockley, E Sapey European Respiratory Journal 46 (suppl 59), 2015 | 15 | 2015 |
Pre-emptive or early adjuvant simvastatin therapy in elderly patients with infection and sepsis JM Patel, H Greenwood, G Walton, J Lord, D Thickett, E Sapey The Lancet 383, S79, 2014 | 5 | 2014 |
S46 phagocytosis by blood neutrophils is not attenuated in patients with chronic obstructive pulmonary disease GM Walton, T Purvis, C Chadwick, RA Stockley, E Sapey Thorax 69 (Suppl 2), A26-A27, 2014 | 3 | 2014 |
Neutrophils from Patients with Alpha 1 Anti-Trypsin Deficiency Show Evidence of Systemic Priming Which May Contribute to Tissue Damage GM Walton, J Moore, HL Greenwood, AKH Usher, AM Turner, E Sapey B101. ACUTE LUNG INJURY AND INFLAMMATION, A3682-A3682, 2015 | 2 | 2015 |
Targeting phosphoinositide 3 kinase reduces damaging neutrophil functions without impairing bacterial phagocytosis in COPD GM Walton, M Begg, A Amour, EM Hessel, AKH Usher, M Pottle, ... B31. INFLAMMATION AND COPD, A2740-A2740, 2015 | 2 | 2015 |
The role of chemokine receptors in the aberrant migration of COPD neutrophils J Stockley, L Peat, G Walton, J Lord, E Sapey European Respiratory Journal 44 (Suppl 58), 2014 | 2 | 2014 |
S114 Simvastatin improves neutrophil migratory targeting in COPD: in vitro studies supporting Statin use as a potential adjuvant therapy CS Sadhra, T Purvis, GM Walton, JA Stockley, RA Stockley, E Sapey Thorax 68 (Suppl 3), A59-A60, 2013 | 2 | 2013 |
S71 Sustained impairment of neutrophil migration following acute exacerbations of chronic obstructive pulmonary disease WJ McIver, M Hughes, GM Walton, RA Stockley, E Sapey Thorax 74 (Suppl 2), A47, 2019 | 1 | 2019 |
Reduced neutrophil migratory function is associated with delirium in older people with pneumonia TA Jackson, F Grudzinska, C Welch, JM Patel, D Parekh, GM Walton, ... Age and Ageing 47, 2018 | 1 | 2018 |
Impaired serum opsonisation of non typeable Haemophilus influenzae in COPD and Alpha-1 Anti-Trypsin Deficiency. A potential mechanism for reduced bacterial clearance? G Walton, A Butler, R Stockley, L Donnelly, E Sapey European Respiratory Journal 50 (suppl 61), 2017 | 1 | 2017 |
Non-typeable haemophilus influenzae is associated with rapid lung function decline and poor macrophage and neutrophil phagocytosis in patients with alpha-1 anti-trypsin deficiency GM Walton, KBR Belchamber, SM Hughes, PJ Barnes, RA Stockley, ... D101. MECHANISTIC AND TRANSLATIONAL STUDIES IN COPD, A7363-A7363, 2017 | 1 | 2017 |