| Site-selective incorporation and ligation of protein aldehydes RJ Spears, MA Fascione Organic & Biomolecular Chemistry 14 (32), 7622-7638, 2016 | 121 | 2016 |
| Tyrosine bioconjugation–an emergent alternative PA Szijj, KA Kostadinova, RJ Spears, V Chudasama Organic & Biomolecular Chemistry 18 (44), 9018-9028, 2020 | 59 | 2020 |
| Cysteine protecting groups: applications in peptide and protein science RJ Spears, C McMahon, V Chudasama Chemical Society Reviews 50 (19), 11098-11155, 2021 | 57 | 2021 |
| Evidence for a Boat Conformation at the Transition State of GH76 α‐1, 6‐Mannanases—Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism AJ Thompson, G Speciale, J Iglesias‐Fernández, Z Hakki, T Belz, ... Angewandte Chemie International Edition 54 (18), 5378-5382, 2015 | 50 | 2015 |
| Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations RJ Spears, RL Brabham, D Budhadev, T Keenan, S McKenna, J Walton, ... Chemical Science 9 (25), 5585-5593, 2018 | 46 | 2018 |
| Disulfide modified IgG1: an investigation of biophysical profile and clinically relevant Fc interactions C Bahou, EA Love, S Leonard, RJ Spears, A Maruani, K Armour, ... Bioconjugate Chemistry 30 (4), 1048-1054, 2019 | 37 | 2019 |
| Palladium-unleashed proteins: gentle aldehyde decaging for site-selective protein modification RL Brabham, RJ Spears, J Walton, S Tyagi, EA Lemke, MA Fascione Chemical communications 54 (12), 1501-1504, 2018 | 23 | 2018 |
| A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability C Bahou, PA Szijj, RJ Spears, A Wall, F Javaid, A Sattikar, EA Love, ... Bioconjugate Chemistry 32 (4), 672-679, 2021 | 16 | 2021 |
| Use of pyridazinediones as extracellular cleavable Linkers through Reversible Cysteine Conjugation C Bahou, RJ Spears, AE Aliev, A Maruani, M Fernandez, F Javaid, ... Chemical Communications 55 (98), 14829-14832, 2019 | 16 | 2019 |
| Structure of the GH76 α-mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron AJ Thompson, F Cuskin, RJ Spears, J Dabin, JP Turkenburg, HJ Gilbert, ... Acta Crystallographica Section D: Biological Crystallography 71 (2), 408-415, 2015 | 13 | 2015 |
| Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif AJ Thompson, RJ Spears, Y Zhu, MDL Suits, SJ Williams, HJ Gilbert, ... Acta Crystallographica Section D: Structural Biology 74 (5), 394-404, 2018 | 11 | 2018 |
| Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C–H activation and C–C bond formation N Ahmed, RJ Spears, TD Sheppard, V Chudasama Chemical Science 13 (29), 8626-8633, 2022 | 9 | 2022 |
| Recent advances in N-and C-terminus cysteine protein bioconjugation RJ Spears, V Chudasama Current Opinion in Chemical Biology 75, 102306, 2023 | 5 | 2023 |
| A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold RJ Spears, C McMahon, M Shamsabadi, C Bahou, IA Thanasi, ... Chemical Communications 58 (5), 645-648, 2022 | 5 | 2022 |
| Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins RJ Spears, A Chrzastek, SY Yap, K Karu, AE Aliev, JR Baker, ... Chemical Communications 58 (35), 5359-5362, 2022 | 4 | 2022 |
| A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations T Keenan, RJ Spears, S Akkad, CS Mahon, NE Hatton, J Walton, A Noble, ... ACS Chemical Biology 16 (11), 2387-2400, 2021 | 4 | 2021 |
| Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus NDJ Yates, RL Brabham, RJ Spears, T Keenan, PA Helliwell, DS Pugh, ... Journal of Chemical Education 96 (6), 1245-1249, 2019 | 3 | 2019 |
| Bioconjugation of polypeptides MA Fascione, RJ Spears, R Brabham, D Budhadev, T Keenan US Patent 11,897,917, 2024 | | 2024 |
| Chemo-and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents S Yap, T Butcher, RJ Spears, C McMahon, I Thanasi, JR Baker, ... Chemical Science, 2024 | | 2024 |
| Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH A Tufail, S Akkad, NE Hatton, NDJ Yates, RJ Spears, T Keenan, A Parkin, ... RSC advances 14 (6), 3723-3729, 2024 | | 2024 |
