Markus Heim
Markus Heim
Professor of Medicine, University of Basel, Switzerland
Email confirmado em unibas.ch
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Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study
A Rauch, Z Kutalik, P Descombes, T Cai, J Di Iulio, T Mueller, M Bochud, ...
Gastroenterology 138 (4), 1338-1345. e7, 2010
13912010
Defective STAT signaling by the leptin receptor in diabetic mice
N Ghilardi, S Ziegler, A Wiestner, R Stoffel, MH Heim, RC Skoda
Proceedings of the National Academy of Sciences 93 (13), 6231-6235, 1996
9981996
MicroRNAs 103 and 107 regulate insulin sensitivity
M Trajkovski, J Hausser, J Soutschek, B Bhat, A Akin, M Zavolan, ...
Nature 474 (7353), 649-653, 2011
8982011
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
J Lucifora, Y Xia, F Reisinger, K Zhang, D Stadler, X Cheng, MF Sprinzl, ...
Science 343 (6176), 1221-1228, 2014
7892014
Interferon signaling and treatment outcome in chronic hepatitis C
M Sarasin-Filipowicz, EJ Oakeley, FHT Duong, V Christen, L Terracciano, ...
Proceedings of the National Academy of Sciences 105 (19), 7034-7039, 2008
7582008
Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification
M Heim, UA Meyer
The Lancet 336 (8714), 529-532, 1990
6021990
Human Arylamine N-Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional Expression
M Blum, DM Grant, W McBride, M Heim, UA Meyer
DNA and cell biology 9 (3), 193-203, 1990
5741990
Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
MH Heim, IM Kerr, GR Stark, JE Darnell
Science 267 (5202), 1347-1349, 1995
5491995
Molecular mechanism of slow acetylation of drugs and carcinogens in humans.
M Blum, A Demierre, DM Grant, M Heim, UA Meyer
Proceedings of the National Academy of Sciences 88 (12), 5237-5241, 1991
4821991
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
A Hagiwara, M Cornu, N Cybulski, P Polak, C Betz, F Trapani, ...
Cell metabolism 15 (5), 725-738, 2012
4722012
Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by …
M Kagimoto, M Heim, K Kagimoto, T Zeugin, UA Meyer
Journal of Biological Chemistry 265 (28), 17209-17214, 1990
4101990
Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
L Quagliata, MS Matter, S Piscuoglio, L Arabi, C Ruiz, A Procino, M Kovac, ...
Hepatology 59 (3), 911-923, 2014
3872014
The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus
MH Heim
Journal of Receptors and Signal Transduction 19 (1-4), 75-120, 1999
3801999
Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
M Sarasin-Filipowicz, J Krol, I Markiewicz, MH Heim, W Filipowicz
Nature medicine 15 (1), 31-33, 2009
3752009
Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway
MH Heim, D Moradpour, HE Blum
Journal of Virology 73 (10), 8469-8475, 1999
3491999
Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C
PY Bochud, T Cai, K Overbeck, M Bochud, JF Dufour, B Müllhaupt, ...
Journal of hepatology 51 (4), 655-666, 2009
3202009
The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota
ML Balmer, E Slack, A De Gottardi, MAE Lawson, S Hapfelmeier, L Miele, ...
Science translational medicine 6 (237), 237ra66-237ra66, 2014
3072014
Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population
F Broly, A Gaedigk, M Heim, M Eichelbaum, K Morike, UA Meyer
DNA and cell biology 10 (8), 545-558, 1991
3021991
Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection: the German guidelines on the management of HCV infection
C Sarrazin, T Berg, RS Ross, P Schirmacher, H Wedemeyer, U Neumann, ...
Zeitschrift fur Gastroenterologie 48 (2), 289-351, 2010
293*2010
Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C
MT Dill, FHT Duong, JE Vogt, S Bibert, PY Bochud, L Terracciano, ...
Gastroenterology 140 (3), 1021-1031. e10, 2011
2912011
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