karen duff
karen duff
Email confirmado em columbia.edu
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Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
autophagy 12 (1), 1-222, 2016
75542016
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
D Morgan, DM Diamond, PE Gottschall, KE Ugen, C Dickey, J Hardy, ...
Nature 408 (6815), 982-985, 2000
19912000
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ...
Nature 383 (6602), 710-713, 1996
19001996
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
L Holcomb, MN Gordon, E McGowan, X Yu, S Benkovic, P Jantzen, ...
Nature medicine 4 (1), 97-100, 1998
15571998
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
J Lewis, E McGowan, J Rockwood, H Melrose, P Nacharaju, ...
Nature genetics 25 (4), 402-405, 2000
13722000
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
LM Refolo, MA Pappolla, B Malester, J LaFrancois, T Bryant-Thomas, ...
Neurobiology of disease 7 (4), 321-331, 2000
11872000
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
WH Yu, AM Cuervo, A Kumar, CM Peterhoff, SD Schmidt, JH Lee, ...
The Journal of cell biology 171 (1), 87-98, 2005
9782005
Trans-synaptic spread of tau pathology in vivo
L Liu, V Drouet, JW Wu, MP Witter, SA Small, C Clelland, K Duff
PloS one 7 (2), e31302, 2012
8662012
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
W Noble, E Planel, C Zehr, V Olm, J Meyerson, F Suleman, K Gaynor, ...
Proceedings of the national academy of sciences 102 (19), 6990-6995, 2005
7862005
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
CA Saura, SY Choi, V Beglopoulos, S Malkani, D Zhang, BSS Rao, ...
Neuron 42 (1), 23-36, 2004
7792004
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
C Andorfer, Y Kress, M Espinoza, R De Silva, KL Tucker, YA Barde, K Duff, ...
Journal of neurochemistry 86 (3), 582-590, 2003
6902003
A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease
LM Refolo, MA Pappolla, J LaFrancois, B Malester, SD Schmidt, ...
Neurobiology of disease 8 (5), 890-899, 2001
6472001
Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
SA Small, K Duff
Neuron 60 (4), 534-542, 2008
6112008
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
J Tsai, J Grutzendler, K Duff, WB Gan
Nature neuroscience 7 (11), 1181-1183, 2004
5752004
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
C Andorfer, CM Acker, Y Kress, PR Hof, K Duff, P Davies
Journal of Neuroscience 25 (22), 5446-5454, 2005
5172005
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
W Noble, V Olm, K Takata, E Casey, O Mary, J Meyerson, K Gaynor, ...
Neuron 38 (4), 555-565, 2003
5042003
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
J Hardy, K Duff, KG Hardy, J Perez-Tur, M Hutton
Nature neuroscience 1 (5), 355-358, 1998
4421998
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits
LA Holcomb, MN Gordon, P Jantzen, K Hsiao, K Duff, D Morgan
Behavior genetics 29 (3), 177-185, 1999
4201999
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease
UA Khan, L Liu, FA Provenzano, DE Berman, CP Profaci, R Sloan, ...
Nature neuroscience 17 (2), 304-311, 2014
4082014
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
JW Wu, M Herman, L Liu, S Simoes, CM Acker, H Figueroa, JI Steinberg, ...
Journal of Biological Chemistry 288 (3), 1856-1870, 2013
4002013
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