Organoid models of human and mouse ductal pancreatic cancer SF Boj, CI Hwang, LA Baker, IIC Chio, DD Engle, V Corbo, M Jager, ... Cell 160 (1), 324-338, 2015 | 1917 | 2015 |
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ... Nature 494 (7436), 247-250, 2013 | 1569 | 2013 |
A living biobank of breast cancer organoids captures disease heterogeneity N Sachs, J De Ligt, O Kopper, E Gogola, G Bounova, F Weeber, ... Cell 172 (1), 373-386. e10, 2018 | 1486 | 2018 |
Long‐term expanding human airway organoids for disease modeling N Sachs, A Papaspyropoulos, DD Zomer‐van Ommen, I Heo, L Böttinger, ... The EMBO journal 38 (4), e100300, 2019 | 778 | 2019 |
Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis M Huch, P Bonfanti, SF Boj, T Sato, CJM Loomans, M Van De Wetering, ... The EMBO journal 32 (20), 2708-2721, 2013 | 705 | 2013 |
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ... Nature protocols 11 (9), 1724-1743, 2016 | 673 | 2016 |
Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene ER Pearson, SF Boj, AM Steele, T Barrett, K Stals, JP Shield, S Ellard, ... PLoS medicine 4 (4), e118, 2007 | 530 | 2007 |
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening E Driehuis, A Van Hoeck, K Moore, S Kolders, HE Francies, ... Proceedings of the National Academy of Sciences 116 (52), 26580-26590, 2019 | 335 | 2019 |
A transcription factor regulatory circuit in differentiated pancreatic cells SF Boj, M Párrizas, MA Maestro, J Ferrer Proceedings of the National Academy of Sciences 98 (25), 14481-14486, 2001 | 307 | 2001 |
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ... Nature medicine 23 (1), 60-68, 2017 | 306 | 2017 |
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal JH van Es, A Haegebarth, P Kujala, S Itzkovitz, BK Koo, SF Boj, J Korving, ... Molecular and cellular biology, 2012 | 300 | 2012 |
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand SF Boj, JH van Es, M Huch, VSW Li, A José, P Hatzis, M Mokry, ... Cell 151 (7), 1595-1607, 2012 | 248 | 2012 |
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas MA Maestro, SF Boj, RF Luco, CE Pierreux, J Cabedo, JM Servitja, ... Human molecular genetics 12 (24), 3307-3314, 2003 | 196 | 2003 |
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids ACF Bolhaqueiro, B Ponsioen, B Bakker, SJ Klaasen, E Kucukkose, ... Nature genetics 51 (5), 824-834, 2019 | 192 | 2019 |
CRISPR-based adenine editors correct nonsense mutations in a cystic fibrosis organoid biobank MH Geurts, E de Poel, GD Amatngalim, R Oka, FM Meijers, ... Cell stem cell 26 (4), 503-510. e7, 2020 | 171 | 2020 |
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids A Marsee, FJM Roos, MMA Verstegen, F Roos, M Verstegen, H Clevers, ... Cell Stem Cell 28 (5), 816-832, 2021 | 169 | 2021 |
Hepatic nuclear factor 1-α directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets M Párrizas, MA Maestro, SF Boj, A Paniagua, R Casamitjana, R Gomis, ... Molecular and cellular biology 21 (9), 3234-3243, 2001 | 160 | 2001 |
Hnf1α (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver JM Servitja, M Pignatelli, MA Maestro, C Cardalda, SF Boj, J Lozano, ... Molecular and cellular biology 29 (11), 2945-2959, 2009 | 150 | 2009 |
Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function SK Hansen, M Párrizas, ML Jensen, S Pruhova, J Ek, SF Boj, A Johansen, ... The Journal of clinical investigation 110 (6), 827-833, 2002 | 146 | 2002 |
Distinct roles of HNF1 Β, HNF1 α, and HNF4 α in regulating pancreas development, Β-cell function and growth MA Maestro, C Cardalda, SF Boj, RF Luco, JM Servitja, J Ferrer Development of the Pancreas and Neonatal Diabetes 12, 33-45, 2007 | 140 | 2007 |