Takeshi Iwatsubo
Takeshi Iwatsubo
Professor of Neuropathology, The University of Tokyo
Email confirmado em m.u-tokyo.ac.jp
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Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines …
RA Sperling, PS Aisen, LA Beckett, DA Bennett, S Craft, AM Fagan, ...
Alzheimer's & dementia 7 (3), 280-292, 2011
54022011
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
IG McKeith, DW Dickson, J Lowe, M Emre, JT O'brien, H Feldman, ...
Neurology 65 (12), 1863-1872, 2005
49742005
Visualization of Aβ42 (43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42 (43)
T Iwatsubo, A Odaka, N Suzuki, H Mizusawa, N Nukina, Y Ihara
Neuron 13 (1), 45-53, 1994
18841994
APP processing and synaptic function
F Kamenetz, T Tomita, H Hsieh, G Seabrook, D Borchelt, T Iwatsubo, ...
Neuron 37 (6), 925-937, 2003
16972003
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
M Baba, S Nakajo, PH Tu, T Tomita, K Nakaya, VM Lee, JQ Trojanowski, ...
The American journal of pathology 152 (4), 879, 1998
16661998
α-Synuclein is phosphorylated in synucleinopathy lesions
H Fujiwara, M Hasegawa, N Dohmae, A Kawashima, E Masliah, ...
Nature cell biology 4 (2), 160-164, 2002
16042002
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
PT Nelson, I Alafuzoff, EH Bigio, C Bouras, H Braak, NJ Cairns, ...
Journal of Neuropathology & Experimental Neurology 71 (5), 362-381, 2012
12762012
Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease
RS Doody, RG Thomas, M Farlow, T Iwatsubo, B Vellas, S Joffe, ...
New England Journal of Medicine 370 (4), 311-321, 2014
12522014
Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium
IG McKeith, BF Boeve, DW Dickson, G Halliday, JP Taylor, D Weintraub, ...
Neurology 89 (1), 88-100, 2017
11872017
AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss
H Hsieh, J Boehm, C Sato, T Iwatsubo, T Tomita, S Sisodia, R Malinow
Neuron 52 (5), 831-843, 2006
10882006
The role of presenilin cofactors in the γ-secretase complex
N Takasugi, T Tomita, I Hayashi, M Tsuruoka, M Niimura, Y Takahashi, ...
Nature 422 (6930), 438-441, 2003
10062003
A phase 3 trial of semagacestat for treatment of Alzheimer's disease
RS Doody, R Raman, M Farlow, T Iwatsubo, B Vellas, S Joffe, K Kieburtz, ...
New England Journal of Medicine 369 (4), 341-350, 2013
8412013
Dominant and differential deposition of distinct β-amyloid peptide species, AβN3 (pE), in senile plaques
TC Saido, T Iwatsubo, DMA Mann, H Shimada, Y Ihara, S Kawashima
Neuron 14 (2), 457-466, 1995
6201995
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein
P Tu, JE Galvin, M Baba, B Giasson, T Tomita, S Leight, S Nakajo, ...
Annals of neurology 44 (3), 415-422, 1998
6101998
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver
K Ito, T Iwatsubo, S Kanamitsu, K Ueda, H Suzuki, Y Sugiyama
Pharmacological reviews 50 (3), 387-412, 1998
5941998
DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers
CF Lippa, JE Duda, M Grossman, HI Hurtig, D Aarsland, BF Boeve, ...
Neurology 68 (11), 812-819, 2007
5792007
Alzheimer's Aβ (1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
DG Cook, MS Forman, JC Sung, S Leight, DL Kolson, T Iwatsubo, ...
Nature medicine 3 (9), 1021-1023, 1997
5641997
Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
M Okochi, J Walter, A Koyama, S Nakajo, M Baba, T Iwatsubo, L Meijer, ...
Journal of Biological Chemistry 275 (1), 390-397, 2000
5592000
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
S Taniguchi, N Suzuki, M Masuda, S Hisanaga, T Iwatsubo, M Goedert, ...
Journal of Biological Chemistry 280 (9), 7614-7623, 2005
5292005
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
T Iwatsubo, N Hirota, T Ooie, H Suzuki, N Shimada, K Chiba, T Ishizaki, ...
Pharmacology & therapeutics 73 (2), 147-171, 1997
5111997
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Artigos 1–20