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Tim Sharpe
Tim Sharpe
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Title
Cited by
Cited by
Year
Chimeric peptidomimetic antibiotics against Gram-negative bacteria
A Luther, M Urfer, M Zahn, M Müller, SY Wang, M Mondal, A Vitale, ...
Nature 576 (7787), 452-458, 2019
2542019
General structural motifs of amyloid protofilaments
N Ferguson, J Becker, H Tidow, S Tremmel, TD Sharpe, G Krause, ...
Proceedings of the National Academy of Sciences 103 (44), 16248-16253, 2006
2042006
Targeting protein–protein interactions and fragment-based drug discovery
E Valkov, T Sharpe, M Marsh, S Greive, M Hyvönen
Fragment-Based Drug Discovery and X-Ray Crystallography, 145-179, 2011
1222011
Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family
N Ferguson, TD Sharpe, PJ Schartau, S Sato, MD Allen, CM Johnson, ...
Journal of molecular biology 353 (2), 427-446, 2005
1092005
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile
S Kleeb, L Pang, K Mayer, D Eris, A Sigl, RC Preston, P Zihlmann, ...
American Chemical Society, 2015
1042015
Distinguishing between cooperative and unimodal downhill protein folding
F Huang, S Sato, TD Sharpe, L Ying, AR Fersht
Proceedings of the National Academy of Sciences 104 (1), 123-127, 2007
1042007
Rapid amyloid fiber formation from the fast-folding WW domain FBP28
N Ferguson, J Berriman, M Petrovich, TD Sharpe, JT Finch, AR Fersht
Proceedings of the National Academy of Sciences 100 (17), 9814-9819, 2003
992003
One-state downhill versus conventional protein folding
N Ferguson, PJ Schartau, TD Sharpe, S Sato, AR Fersht
Journal of molecular biology 344 (2), 295-301, 2004
912004
Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry
CA Smith, X Li, TH Mize, TD Sharpe, EI Graziani, C Abell, WTS Huck
Analytical chemistry 85 (8), 3812-3816, 2013
842013
Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger cyclic di-GMP
A Sundriyal, C Massa, D Samoray, F Zehender, T Sharpe, U Jenal, ...
Journal of Biological Chemistry 289 (10), 6978-6990, 2014
832014
Structural basis for Par-4 recognition by the SPRY domain-and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4
P Filippakopoulos, A Low, TD Sharpe, J Uppenberg, S Yao, Z Kuang, ...
Journal of molecular biology 401 (3), 389-402, 2010
752010
A molecular mechanism of chaperone-client recognition
L He, T Sharpe, A Mazur, S Hiller
Science advances 2 (11), e1601625, 2016
732016
A DNA‐Encoded Chemical Library Incorporating Elements of Natural Macrocycles
CJ Stress, B Sauter, LA Schneider, T Sharpe, D Gillingham
Angewandte Chemie International Edition 58 (28), 9570-9574, 2019
632019
CDKL family kinases have evolved distinct structural features and ciliary function
P Canning, K Park, J Gonçalves, C Li, CJ Howard, TD Sharpe, LJ Holt, ...
Cell reports 22 (4), 885-894, 2018
562018
Syrosingopine sensitizes cancer cells to killing by metformin
D Benjamin, M Colombi, SK Hindupur, C Betz, HA Lane, ...
Science advances 2 (12), e1601756, 2016
532016
The dynamic dimer structure of the chaperone Trigger Factor
L Morgado, BM Burmann, T Sharpe, A Mazur, S Hiller
Nature communications 8 (1), 1-11, 2017
522017
Analysis of'downhill'protein folding
N Ferguson, TD Sharpe, CM Johnson, PJ Schartau, AR Fersht
Nature 445 (7129), E14-E15, 2007
502007
The role of the turn in β‐hairpin formation during WW domain folding
T Sharpe, AL Jonsson, TJ Rutherford, V Daggett, AR Fersht
Protein Science 16 (10), 2233-2239, 2007
462007
The folding mechanism of BBL: plasticity of transition-state structure observed within an ultrafast folding protein family
H Neuweiler, TD Sharpe, TJ Rutherford, CM Johnson, MD Allen, ...
Journal of molecular biology 390 (5), 1060-1073, 2009
452009
A high-resolution description of β 1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
A Grahl, LA Abiko, S Isogai, T Sharpe, S Grzesiek
Nature communications 11 (1), 1-13, 2020
402020
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Articles 1–20