| Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties NM Urs, SM Gee, TF Pack, JD McCorvy, T Evron, JC Snyder, X Yang, ... Proceedings of the National Academy of Sciences 113 (50), E8178-E8186, 2016 | 138 | 2016 |
| Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor SM Peterson, TF Pack, AD Wilkins, NM Urs, DJ Urban, CE Bass, ... Proceedings of the National Academy of Sciences 112 (22), 7097-7102, 2015 | 100 | 2015 |
| Effect of various decontamination procedures on disposable N95 mask integrity and SARS-CoV-2 infectivity JS Smith, H Hanseler, J Welle, R Rattray, M Campbell, T Brotherton, ... Journal of clinical and translational science 5 (1), e10, 2021 | 83 | 2021 |
| Noncanonical scaffolding of Gαi and β-arrestin by G protein–coupled receptors JS Smith, TF Pack, A Inoue, C Lee, K Zheng, I Choi, DS Eiger, A Warman, ... Science 371 (6534), eaay1833, 2021 | 78 | 2021 |
| CXC motif chemokine receptor 3 splice variants differentially activate beta-arrestins to regulate downstream signaling pathways JS Smith, P Alagesan, NK Desai, TF Pack, JH Wu, A Inoue, NJ Freedman, ... Molecular pharmacology 92 (2), 136-150, 2017 | 62 | 2017 |
| The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation TF Pack, MI Orlen, C Ray, SM Peterson, MG Caron Journal of Biological Chemistry 293 (16), 6161-6171, 2018 | 47 | 2018 |
| Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents C Peng, MR Kimbrell, C Tian, TF Pack, PA Crooks, EK Fifer, RL Papke Molecular pharmacology 84 (3), 459-475, 2013 | 34 | 2013 |
| Engineered D2R variants reveal the balanced and biased contributions of G-protein and β-arrestin to dopamine-dependent functions SJ Rose, TF Pack, SM Peterson, K Payne, E Borrelli, MG Caron Neuropsychopharmacology 43 (5), 1164-1173, 2018 | 28 | 2018 |
| A rapid and affordable screening platform for membrane protein trafficking JC Snyder, TF Pack, LK Rochelle, SK Chakraborty, M Zhang, AW Eaton, ... BMC biology 13, 1-10, 2015 | 26 | 2015 |
| Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness JC Snyder, LK Rochelle, C Ray, TF Pack, CB Bock, V Lubkov, HK Lyerly, ... Journal of Biological Chemistry 292 (17), 7208-7222, 2017 | 24 | 2017 |
| Receptor, ligand and transducer contributions to dopamine D2 receptor functional selectivity SM Peterson, TF Pack, MG Caron PLoS One 10 (10), e0141637, 2015 | 20 | 2015 |
| Noncanonical interactions of G proteins and β‐arrestins: from competitors to companions JS Smith, TF Pack The FEBS Journal 288 (8), 2550-2561, 2021 | 12 | 2021 |
| Ghrelin receptor antagonism of hyperlocomotion in cocaine‐sensitized mice requires βarrestin‐2 K Toth, LM Slosky, TF Pack, NM Urs, P Boone, L Mao, D Abraham, ... Synapse 72 (1), e22012, 2018 | 12 | 2018 |
| Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes K Zheng, JS Smith, DS Eiger, A Warman, I Choi, CC Honeycutt, ... Science Signaling 15 (726), eabg5203, 2022 | 11 | 2022 |
| Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho MR MacLean, B Fanburg, N Hill, HM Lazarus, TF Pack, M Palacios, ... Comprehensive Physiology 12 (4), 4103-4118, 2011 | 11 | 2011 |
| Measuring nonapoptotic caspase activity with a transgenic reporter in mice PJ Nicholls, TF Pack, NM Urs, S Kumar, Y Zhou, G Ichim, JD Ginzel, ... Eneuro 9 (5), 2022 | 4 | 2022 |
| Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension S Wring, M Alonso-Galicia, T Pack, J Rurka, D Carpenter, M Rhodes US Patent 11,413,287, 2022 | 4 | 2022 |
| Method for treating sarcoidosis-associated pulmonary hypertension T Pack, S Rajagopal US Patent App. 16/714,227, 2020 | 4 | 2020 |
| Method for treating interstitial lung disease T Pack, M Alonso-Galicia US Patent App. 16/714,260, 2020 | 4 | 2020 |
| Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing M Alonso-Galicia, D Carpenter, T Pack, M Rhodes, J Rurka, S Wring US Patent 11,576,915, 2023 | 3 | 2023 |
