Gopal Thinakaran
Gopal Thinakaran
Associate Dean for Neuroscience Research, USF Morsani College of Medicine
Email confirmado em usf.edu
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Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ...
Neuron 17 (5), 1005-1013, 1996
19041996
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
G Thinakaran, DR Borchelt, MK Lee, HH Slunt, L Spitzer, G Kim, ...
Neuron 17 (1), 181-190, 1996
12651996
Amyloid precursor protein trafficking, processing, and function
G Thinakaran, EH Koo
Journal of Biological Chemistry 283 (44), 29615-29619, 2008
12352008
The role of presenilin cofactors in the γ-secretase complex
N Takasugi, T Tomita, I Hayashi, M Tsuruoka, M Niimura, Y Takahashi, ...
Nature 422 (6930), 438-441, 2003
10332003
Trafficking and proteolytic processing of APP
C Haass, C Kaether, G Thinakaran, S Sisodia
Cold Spring Harbor perspectives in medicine 2 (5), a006270, 2012
8912012
Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
H Xu, GK Gouras, JP Greenfield, B Vincent, J Naslund, L Mazzarelli, ...
Nature medicine 4 (4), 447-451, 1998
6371998
Protein topology of presenilin 1
A Doan, G Thinakaran, DR Borchelt, HH Slunt, T Ratovitsky, M Podlisny, ...
Neuron 17 (5), 1023-1030, 1996
4981996
Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes
KS Vetrivel, H Cheng, W Lin, T Sakurai, T Li, N Nukina, PC Wong, H Xu, ...
Journal of Biological Chemistry 279 (43), 44945-44954, 2004
4832004
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
D Levitan, TG Doyle, D Brousseau, MK Lee, G Thinakaran, HH Slunt, ...
Proceedings of the National Academy of Sciences 93 (25), 14940-14944, 1996
4711996
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
JP Greenfield, J Tsai, GK Gouras, B Hai, G Thinakaran, F Checler, ...
Proceedings of the National Academy of Sciences 96 (2), 742-747, 1999
4551999
Effects of PS1 deficiency on membrane protein trafficking in neurons
S Naruse, G Thinakaran, JJ Luo, JW Kusiak, T Tomita, T Iwatsubo, X Qian, ...
Neuron 21 (5), 1213-1221, 1998
4491998
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice
CS Von Koch, H Zheng, H Chen, M Trumbauer, G Thinakaran, ...
Neurobiology of aging 18 (6), 661-669, 1997
4271997
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
HH Slunt, G Thinakaran, C Von Koch, AC Lo, RE Tanzi, SS Sisodia
Journal of Biological Chemistry 269 (4), 2637-2644, 1994
4241994
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
G Thinakaran, CL Harris, T Ratovitski, F Davenport, HH Slunt, DL Price, ...
Journal of Biological Chemistry 272 (45), 28415-28422, 1997
4051997
Metabolism of the “Swedish” amyloid precursor protein variant in neuro2a (N2a) cells: evidence that cleavage at the “β-secretase” site occurs in the Golgi apparatus
G Thinakaran, DB Teplow, R Siman, B Greenberg, SS Sisodia
Journal of Biological Chemistry 271 (16), 9390-9397, 1996
3621996
Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
H Xu, D Sweeney, R Wang, G Thinakaran, ACY Lo, SS Sisodia, ...
Proceedings of the National Academy of Sciences 94 (8), 3748-3752, 1997
3591997
Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues
MK Lee, HH Slunt, LJ Martin, G Thinakaran, G Kim, SE Gandy, M Seeger, ...
Journal of Neuroscience 16 (23), 7513-7525, 1996
3341996
Comparative evaluation of synaptophysin-based methods for quantification of synapses
ME Calhoun, M Jucker, LJ Martin, G Thinakaran, DL Price, PR Mouton
Journal of neurocytology 25 (1), 821-828, 1996
3201996
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1
W Luo, H Wang, H Li, BS Kim, S Shah, HJ Lee, G Thinakaran, TW Kim, ...
Journal of Biological Chemistry 278 (10), 7850-7854, 2003
3162003
Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path
JD Buxbaum, G Thinakaran, V Koliatsos, J O’Callahan, HH Slunt, ...
Journal of Neuroscience 18 (23), 9629-9637, 1998
3001998
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