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Iakov N Rudenko
Iakov N Rudenko
Neurohospitalist, UPMC Western Maryland
Email confirmado em wmhs.com
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Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
A Beilina, IN Rudenko, A Kaganovich, L Civiero, H Chau, SK Kalia, ...
Proceedings of the National Academy of Sciences 111 (7), 2626-2631, 2014
3892014
mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex
AA Dillman, DN Hauser, JR Gibbs, MA Nalls, MK McCoy, IN Rudenko, ...
Nature neuroscience 16 (4), 499-506, 2013
1502013
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation
IN Rudenko, A Kaganovich, DN Hauser, A Beylina, R Chia, J Ding, ...
Biochemical Journal 446 (1), 99-111, 2012
1312012
Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation
G Liu, J Yu, J Ding, C Xie, L Sun, I Rudenko, W Zheng, N Sastry, J Luo, ...
The Journal of clinical investigation 124 (7), 3032-3046, 2014
1292014
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
E Lobbestael, J Zhao, IN Rudenko, A Beylina, F Gao, J Wetter, M Beullens, ...
Biochemical Journal, 2013
1092013
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7
R Chia, S Haddock, A Beilina, IN Rudenko, A Mamais, A Kaganovich, Y Li, ...
Nature communications 5 (1), 5827, 2014
1072014
Hexokinase activity is required for recruitment of parkin to depolarized mitochondria
MK McCoy, A Kaganovich, IN Rudenko, J Ding, MR Cookson
Human molecular genetics 23 (1), 145-156, 2014
972014
Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
IN Rudenko, R Chia, MR Cookson
BMC medicine 10, 1-8, 2012
772012
Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications
IN Rudenko, MR Cookson
Neurotherapeutics 11 (4), 738-750, 2014
662014
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
L Pellegrini, DN Hauser, Y Li, A Mamais, A Beilina, R Kumaran, A Wetzel, ...
Human molecular genetics 27 (18), 3257-3271, 2018
612018
The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2
IN Rudenko, A Kaganovich, RG Langston, A Beilina, K Ndukwe, ...
Biochemical Journal 474 (9), 1547-1558, 2017
402017
The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research
RG Langston, IN Rudenko, MR Cookson
Biochemical Journal 473 (3), 221-232, 2016
342016
14-3-3 proteins are promising LRRK2 interactors
IN Rudenko, MR Cookson
Biochem. J 430, e5-e6, 2010
292010
Differences in stability, activity and mutation effects between human and mouse leucine-rich repeat kinase 2
RG Langston, IN Rudenko, R Kumaran, DN Hauser, A Kaganovich, ...
Neurochemical research 44, 1446-1459, 2019
102019
Two molecular motility systems of the frog olfactory cilia
VO Samoilov, EV Bigdai, IN Rudenko, VV Bekusova, BA Dudich
Biophysics 53 (6), 539-543, 2008
52008
Effects of lithium on isolated rat heart mitochondria
SM Korotkov, VP Nesterov, IN Rudenko, IV Brailovskaya
Doklady. Biochemistry and Biophysics 430 (1), 45, 2010
32010
Kinetics of Ca2+, NADH, and oxidized flavoproteins in the frog olfactory lining under the effect of odorants
IN Rudenko, EV Bigdaĭ, VO Samoĭlov
Biofizika 52 (1), 88, 2007
32007
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