Paul Saftig
Paul Saftig
Professor of Biochemistry
Email confirmado em - Página inicial
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Citado por
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
L Apetoh, F Ghiringhelli, A Tesniere, M Obeid, C Ortiz, A Criollo, G Mignot, ...
Nature medicine 13 (9), 1050-1059, 2007
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ...
Nature 398 (6727), 518-522, 1999
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
B De Strooper, P Saftig, K Craessaerts, H Vanderstichele, G Guhde, ...
Nature 391 (6665), 387-390, 1998
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
P Saftig, J Klumperman
Nature reviews Molecular cell biology 10 (9), 623-635, 2009
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
U Sahin, G Weskamp, K Kelly, HM Zhou, S Higashiyama, J Peschon, ...
The Journal of cell biology 164 (5), 769-779, 2004
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
P Saftig, E Hunziker, O Wehmeyer, S Jones, A Boyde, W Rommerskirch, ...
Proceedings of the National Academy of Sciences 95 (23), 13453-13458, 1998
Role for Rab7 in maturation of late autophagic vacuoles
S Jäger, C Bucci, I Tanida, T Ueno, E Kominami, P Saftig, EL Eskelinen
Journal of cell science 117 (20), 4837-4848, 2004
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
Y Tanaka, G Guhde, A Suter, EL Eskelinen, D Hartmann, ...
Nature 406 (6798), 902-906, 2000
Control of peripheral nerve myelination by the ß-secretase BACE1
M Willem, AN Garratt, B Novak, M Citron, S Kaufmann, A Rittger, ...
Science 314 (5799), 664-666, 2006
Autophagy: a lysosomal degradation pathway with a central role in health and disease
EL Eskelinen, P Saftig
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1793 (4), 664-673, 2009
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts
D Hartmann, B De Strooper, L Serneels, K Craessaerts, A Herreman, ...
Human molecular genetics 11 (21), 2615-2624, 2002
At the acidic edge: emerging functions for lysosomal membrane proteins
EL Eskelinen, Y Tanaka, P Saftig
Trends in cell biology 13 (3), 137-145, 2003
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation
T Maretzky, K Reiss, A Ludwig, J Buchholz, F Scholz, E Proksch, ...
Proceedings of the National Academy of Sciences 102 (26), 9182-9187, 2005
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
C Hundhausen, D Misztela, TA Berkhout, N Broadway, P Saftig, K Reiss, ...
Blood 102 (4), 1186-1195, 2003
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
Z Zhang, H Hartmann, VM Do, D Abramowski, C Sturchler-Pierrat, ...
Nature 395 (6703), 698-702, 1998
LAMP proteins are required for fusion of lysosomes with phagosomes
KK Huynh, EL Eskelinen, CC Scott, A Malevanets, P Saftig, S Grinstein
The EMBO journal 26 (2), 313-324, 2007
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
RA González-Polo, P Boya, AL Pauleau, A Jalil, N Larochette, ...
Journal of cell science 118 (14), 3091-3102, 2005
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 …
A Herreman, D Hartmann, W Annaert, P Saftig, K Craessaerts, L Serneels, ...
Proceedings of the National Academy of Sciences 96 (21), 11872-11877, 1999
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane‐bound form by the sheddase a disintegrin and …
A Raucci, S Cugusi, A Antonelli, SM Barabino, L Monti, A Bierhaus, ...
The FASEB Journal 22 (10), 3716-3727, 2008
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