An open-source drug discovery platform enables ultra-large virtual screens C Gorgulla, A Boeszoermenyi, ZF Wang, PD Fischer, PW Coote, ... Nature 580 (7805), 663-668, 2020 | 430 | 2020 |
Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents WC Huang, TY Tseng, YT Chen, CC Chang, ZF Wang, CL Wang, TN Hsu, ... Nucleic acids research 43 (21), 10102-10113, 2015 | 131 | 2015 |
The hairpin form of r (G4C2) exp in c9ALS/FTD is repeat-associated non-ATG translated and a target for bioactive small molecules ZF Wang, A Ursu, JL Childs-Disney, R Guertler, WY Yang, V Bernat, ... Cell chemical biology 26 (2), 179-190. e12, 2019 | 96 | 2019 |
NIN-like protein 7 transcription factor is a plant nitrate sensor KH Liu, M Liu, Z Lin, ZF Wang, B Chen, C Liu, A Guo, M Konishi, ... Science 377 (6613), 1419-1425, 2022 | 89 | 2022 |
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs M Zhang, M Gui, ZF Wang, C Gorgulla, JJ Yu, H Wu, ZJ Sun, C Klenk, ... Nature structural & molecular biology 28 (3), 258-267, 2021 | 81 | 2021 |
Approved anti-cancer drugs target oncogenic non-coding RNAs SP Velagapudi, MG Costales, BR Vummidi, Y Nakai, AJ Angelbello, ... Cell Chemical Biology 25 (9), 1086-1094. e7, 2018 | 79 | 2018 |
Using genome sequence to enable the design of medicines and chemical probes AJ Angelbello, JL Chen, JL Childs-Disney, P Zhang, ZF Wang, MD Disney Chemical reviews 118 (4), 1599-1663, 2018 | 73 | 2018 |
Structural basis of sodium–potassium exchange of a human telomeric DNA quadruplex without topological conversion ZF Wang, MH Li, STD Hsu, TC Chang Nucleic acids research 42 (7), 4723-4733, 2014 | 62 | 2014 |
A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening C Gorgulla, KMP Das, KE Leigh, M Cespugli, PD Fischer, ZF Wang, ... Iscience 24 (2), 2021 | 60 | 2021 |
In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands TY Tseng, ZF Wang, CH Chien, TC Chang Nucleic acids research 41 (22), 10605-10618, 2013 | 60 | 2013 |
Conformational Transition of a Hairpin Structure to G-Quadruplex within the WNT1 Gene Promoter MHJ Kuo, ZF Wang, TY Tseng, MH Li, STD Hsu, JJ Lin, TC Chang Journal of the American Chemical Society 137 (1), 210-218, 2015 | 59 | 2015 |
Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers JM Wang, FC Huang, MHJ Kuo, ZF Wang, TY Tseng, LC Chang, SJ Yen, ... Journal of Biological Chemistry 289 (21), 14612-14623, 2014 | 53 | 2014 |
A massively parallel selection of small molecule-RNA motif binding partners informs design of an antiviral from sequence JL Childs-Disney, T Tran, BR Vummidi, SP Velagapudi, HS Haniff, ... Chem 4 (10), 2384-2404, 2018 | 45 | 2018 |
Expression of the human telomerase reverse transcriptase gene is modulated by quadruplex formation in its first exon due to DNA methylation PT Li, ZF Wang, YM Kuan, MH Li, MC Huang, PC Chiang, TC Chang, ... Journal of Biological Chemistry 292 (51), 20859-20870, 2017 | 36 | 2017 |
Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity CC Kang, WC Huang, CW Kouh, ZF Wang, CC Cho, CC Chang, CL Wang, ... Integrative biology 5 (10), 1217-1228, 2013 | 34 | 2013 |
A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes ZF Wang, MH Li, WW Chen, STD Hsu, TC Chang Nucleic Acids Research 44 (8), 3958-3968, 2016 | 33 | 2016 |
Chemical modulation of DNA replication along G-quadruplex based on topology-dependent ligand binding S Takahashi, A Kotar, H Tateishi-Karimata, S Bhowmik, ZF Wang, ... Journal of the American Chemical Society 143 (40), 16458-16469, 2021 | 28 | 2021 |
A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress PC Wei, ZF Wang, WT Lo, MI Su, JY Shew, TC Chang, WH Lee Nucleic acids research 41 (3), 1533-1543, 2013 | 28 | 2013 |
Structural conversion of intramolecular and intermolecular G-quadruplexes of bcl2mid: the effect of potassium concentration and ion exchange CT Lin, TY Tseng, ZF Wang, TC Chang The Journal of Physical Chemistry B 115 (10), 2360-2370, 2011 | 27 | 2011 |
Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol ZF Wang, TC Chang Nucleic acids research 40 (17), 8711-8720, 2012 | 25 | 2012 |