Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin JD Powers, CC Yuan, KJ McCabe, JD Murray, MC Childers, GV Flint, ... Proceedings of the National Academy of Sciences 116 (23), 11502-11507, 2019 | 37 | 2019 |
Contributions of Ca2+-independent thin filament activation to cardiac muscle function Y Aboelkassem, JA Bonilla, KJ McCabe, SG Campbell Biophysical Journal 109 (10), 2101-2112, 2015 | 31 | 2015 |
Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation An Integrated Multiscale Modeling Study S Dewan, KJ McCabe, M Regnier, AD McCulloch, S Lindert The Journal of Physical Chemistry B 120 (33), 8264-8275, 2016 | 22 | 2016 |
Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes KJ McCabe, P Rangamani Journal of molecular and cellular cardiology 154, 32-40, 2021 | 11 | 2021 |
A stochastic multiscale model of cardiac thin filament activation using Brownian-Langevin dynamics Y Aboelkassem, KJ McCabe, GA Huber, M Regnier, JA McCammon, ... Biophysical journal 117 (12), 2255-2272, 2019 | 10 | 2019 |
Multiscale models of cardiac muscle biophysics and tissue remodeling in hypertrophic cardiomyopathies Y Aboelkassem, JD Powers, KJ McCabe, AD McCulloch Current opinion in biomedical engineering 11, 35-44, 2019 | 9 | 2019 |
Insights and challenges of multi-scale modeling of sarcomere mechanics in cTn and tm DCM mutants—genotype to cellular phenotype S Dewan, KJ McCabe, M Regnier, AD McCulloch Frontiers in Physiology 8, 240453, 2017 | 9 | 2017 |
Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks MH Mesa, J van den Brink, WE Louch, KJ McCabe, P Rangamani Biophysical Journal 121 (3), 378a, 2022 | 7* | 2022 |
Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere KJ McCabe, Y Aboelkassem, AE Teitgen, GA Huber, JA McCammon, ... Archives of biochemistry and biophysics 695, 108582, 2020 | 6 | 2020 |
Turning the azimuthal motions of adjacent tropomyosins into a coupled n-body problem in a brownian model of cardiac thin filament activation Y Aboelkassem, KJ McCabe, G Huber, J Sundnes, AD McCulloch Biophysical Journal 114 (3), 502a-503a, 2018 | 5 | 2018 |
Investigating the Multiscale Impact of Deoxyadenosine Triphosphate (dATP) on Pulmonary Arterial Hypertension (PAH) Induced Heart Failure K Garcia, M Hock, V Jaltare, C Uysalel, KJ McCabe, A Teitgen, ... Computational Physiology: Simula Summer School 2021− Student Reports, 77-90, 2022 | 1 | 2022 |
Exploring the effects of 2. deoxy-atp on serca 2a using multiscale modeling KJ McCabe, SP Hirakis, AE Teitgen, AB Duclos, M Regnier, RE Amaro, ... Biophysical Journal 118 (3), 260a, 2020 | 1 | 2020 |
Molecular effects of cardiac troponin DCM mutations on calcium sensitivity and Myofilament activation-an integrated multi-scale modeling study S Dewan, K McCabe, M Regnier, A McCulloch, S Lindert Biophysical Journal 112 (3), 322a, 2017 | 1 | 2017 |
Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks MH Mesa, G Garcia, F Hoerndli, KJ McCabe, P Rangamani Biophysical Journal 123 (3), 415a, 2024 | | 2024 |
Computational Physiology: Simula Summer School 2023− Student Reports KJ McCabe Springer Nature, 2024 | | 2024 |
Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks GC Garcia, F Hoerndli, KJ McCabe, P Rangamani | | 2023 |
Multiscale computational modeling of the effects of 2’-deoxy-ATP on cardiac muscle calcium handling MT Hock, AE Teitgen, KJ McCabe, SP Hirakis, GA Huber, M Regnier, ... Journal of Applied Physics 134 (7), 2023 | | 2023 |
Multiscale simulations of the effects of 2’-deoxy-ATP and a myosin mutation on actomyosin interactions M Hock, MC Childers, AE Teitgen, G Huber, KJ McCabe, JA McCammon, ... Biophysical Journal 121 (3), 291a, 2022 | | 2022 |
2-Deoxy-ATP improves ventricular function via combined effects on myosin recruitment from the super-relaxed state, crossbridge cycling and calcium dynamics in healthy and … AE Teitgen, KJ McCabe, M Hock, DA Beard, M Regnier, AD McCulloch Biophysical Journal 121 (3), 435a, 2022 | | 2022 |
A Coupled Electromechanical Myocyte Model to Assess the Effects of 2‐deoxy‐ATP on Contractile Function in the Heart A Teitgen, K McCabe, M Hock, M Regnier, A McCulloch The FASEB Journal 34 (S1), 1-1, 2020 | | 2020 |